Gerald Dienel

High Impact

UAMS Contingent Worker

University of Arkansas for Medical Sciences

faculty

Neurology, College of Medicine

47 h-index 151 pubs 10,483 cited

Research Areas

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Gerald Dienel's research focuses on brain energy metabolism and its implications for neuroimaging and neurological disorders. His work investigates the intricate relationship between neuronal activity, glucose utilization, and the maintenance of brain homeostasis. Dienel has explored how processes such as nonoxidative glycolysis and glycogenolysis contribute to neurovascular coupling, enabling the brain to maintain stable levels of pH, pCO2, and pO2 during activation.

His recent publications delve into specific aspects of brain metabolism, including the role of glycogen in epilepsy and the metabolic reprogramming observed in models of familial ALS. Dienel also addresses methodological considerations in brain research, such as preventing artifacts during tissue harvesting. His research group's efforts contribute to a deeper understanding of fundamental brain functions and their dysregulation in disease states, with potential applications for improving diagnostic techniques and therapeutic strategies.

Metrics

h-index: 47
Publications: 151
Citations: 10,483

Selected Publications

Reply to Comment by Quistorff: ATP is not consumed solely by hydrolytic reactions (2025) DOI
Comment on the Editorial “Embracing the Modern Biochemistry of Brain Metabolism” (2025) DOI
A Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons (2025) DOI
Reduced removal of waste products from energy metabolism takes center stage in human brain aging (2025) DOI
Setting standards for brain collection procedures in metabolomic studies (2025) DOI
Does hyperphenylalaninemia induce brain glucose hypometabolism? Cerebral spinal fluid findings in treated adult phenylketonuric patients (2024) DOI
Does Hyperphenylalaninemia Induce Brain Glucose Hypometabolism? Cerebral Spinal Fluid (CSF) Findings in Treated Adult Phenylketonuric (PKU) Patients (2024) DOI
Brain energy metabolism: A roadmap for future research (2024) DOI
A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments (2023) DOI
Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2 (2023) DOI
A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and pharmacology identifies important, unresolved topics for future studies (2023) DOI
In vivo calibration of genetically encoded metabolite biosensors must account for metabolite metabolism during calibration and cellular volume (2023) DOI
Potential new roles for glycogen in epilepsy (2022) DOI
Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model (2022) DOI
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy (2022) DOI

Grants & Funding

Endoplasmic reticulum stress in diabetic brain NIH Principal Investigator
Neuroscience Research Center Core Facility at UAMS NIH Co-Investigator
Functional Metabolism in Working Brain NIH Principal Investigator
Astrocyte metabolite trafficking and brain imaging in Alzheimer model mice Alzheimer's Association Principal Investigator
Glial Biology Gordon Research Conference NIH Co-Principal Investigator
Functional activity in glia NIH Principal Investigator
Astrocyte metabolite trafficking and brain imaging in Alzheimer model mice Alzheimer's Association Principal Investigator
FUNCTIONAL METABOLIC ACTIVITY IN GLIA IN VIVO NIH Principal Investigator