Jinhu Xiong

Federal Grant PI High Impact

Associate Professor

University of Arkansas for Medical Sciences

faculty

Orthopaedics Surgery, College of Medicine

22 h-index 38 pubs 4,164 cited

Research Areas

Links

ORCID Lab Website UAMS TRI Profile

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Jinhu Xiong is an Associate Professor in Orthopaedics Surgery at the University of Arkansas for Medical Sciences. His research focuses on bone mechanobiology and the role of specific cellular signaling pathways in maintaining skeletal health, particularly in the context of aging and disease. Xiong has received federal funding from the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases for his work investigating the function of Piezo1 in bone homeostasis and mechanotransduction. His laboratory actively studies how mechanical forces influence bone cells and seeks to develop mechanobiology-based treatments to mitigate bone loss associated with aging and chemotherapy.

Xiong's recent publications explore various aspects of bone biology, including the function of the Piezo1 channel in osteocytes and its impact on mitochondrial signaling, the identity of mesenchymal cell types in bone, and strategies to counteract age-related bone loss. He has also investigated the role of autophagy regulators in bone mass and strength. His scholarly work has resulted in a h-index of 22 and over 4,000 citations across his 38 publications. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Melda Onal, Charles A. O’Brien, and Maria Almeida.

Metrics

h-index: 22
Publications: 38
Citations: 4,164

Selected Publications

The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025) DOI
Different effects of moderate tibial loading and Yoda1 on breast cancer-induced osteolysis in aged mice (2025) DOI
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025) DOI
Piezo1 expression in mature osteocytes is dispensable for the skeletal response to mechanical loading (2024) DOI
Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments (2024) DOI
Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024) DOI
A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone (2023) DOI
Piezo1 opposes age‐associated cortical bone loss (2023) DOI
Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling (2022) DOI
Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo (2021) DOI
New Advances in Osteocyte Mechanotransduction (2021) DOI

Federal Grants 1 $324,368 total

NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases Contact PI Aug 2020 - Jun 2026

The role of Piezo1 in bone homeostasis and mechanotransduction

National Institute of Arthritis and Musculoskeletal and Skin Diseases $324,368 R01

Grants & Funding

Osteocyte Control of Bone Remodeling NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
The role of Piezo 1 in bone homeostasis and mechanotransduction NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator