William E. Fantegrossi
Professor
University of Arkansas for Medical Sciences
faculty
Pharmacology & Toxicology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
William E. Fantegrossi's research focuses on the pharmacological effects and toxicity of various psychoactive substances, including synthetic cannabinoids, substituted amphetamines, and novel arylcyclohexylamines. He investigates their interactions with specific receptor systems, such as CB1 receptors and monoamine transporters, and examines their behavioral and neurocognitive effects in preclinical models. His work also explores structure-activity relationships to understand how chemical modifications influence drug efficacy and safety profiles.
Fantegrossi has published extensively on these topics, with a h-index of 40 and over 5,000 citations. He has received federal funding, including a $496,311 award from the NIH/National Institute on Drug Abuse for translational training in addiction. His research group includes collaborators such as Brenda M. Gannon and Jeffery H. Moran from the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications.
His recent publications address the abuse liability and psychosis-like effects of novel drugs, the development of analytical testing technologies for drug-facilitated crimes, and the potential therapeutic applications of compounds like MDMA for conditions such as Autism Spectrum Disorder. Fantegrossi's work contributes to understanding the complex pharmacology of abused substances and informs strategies for drug development and forensic analysis.
Metrics
- h-index: 40
- Publications: 164
- Citations: 5,066
Selected Publications
- Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses (2026) DOI
- Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations (2025) DOI
- Effects of psychostimulants on locomotor activity in the BTBR T+ Itpr3tf/J mouse: implications for comorbid autism spectrum disorder and attention deficit hyperactivity disorder (2025) DOI
- In vitro and in vivo pharmacological characterization of fentanyl analogs (2025) DOI
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption (2025) DOI
- NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025) DOI
- DRUG-DRUG INTERACTIONS RELEVANT TO SUBSTANCE ABUSE AND TOXICITY (2025) DOI
- Respiratory Depressant Effects of Fentanyl in Combination With Synthetic Cannabinoid Receptor Agonists: A Potential Mechanism for “Narcan-Resistant” Overdose (2024) DOI
- Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917] (2024) DOI
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents (2024) DOI
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones (2023) DOI
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations (2023) DOI
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety (2023) DOI
- Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019) (2023) DOI
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes (2022) DOI
Federal Grants 1 $496,311 total
Grants & Funding
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- Effects of self-administered MDMA on brain and behavior in rhesus monkeys NIH Principal Investigator
- No FP attached UAMS College of Medicine Principal Investigator
- No FP attached UAMS College of Medicine Principal Investigator
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- In vivo pharmacological studies for abuse liability testing - Continuation U.S. Food and Drug Administration Principal Investigator
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
Collaborators
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