Karl D. Straub

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

28 h-index 136 pubs 2,822 cited

Research Areas

Phytochemicals and Antioxidant Activities Receptor Mechanisms and Signaling Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Diet and metabolism studies Synthesis and biological activity Health and Medical Research Impacts

Links

Lab Website

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OverviewAI-generated summary

Karl D. Straub's research focuses on the chemical reactions involving hydrogen sulfide (H2S) and quinones, particularly naphthoquinones and polyphenols. His work investigates how these compounds, including those found in 'antioxidant' berries and Coenzyme Q10, oxidize H2S to polysulfides and thiosulfate. This mechanism is explored for its implications in the biological actions and potential therapeutic applications of these substances.

His publications detail the redox and nucleophilic reactions of naphthoquinones with small thiols and their subsequent effects on H2S oxidation. Straub also examines the broader impact of 'antioxidant' nutraceuticals on cellular sulfur metabolism and signaling. His scholarship metrics include an h-index of 28, with 136 total publications and 2,822 total citations, and he is recognized as a highly cited researcher. Straub maintains an active laboratory website.

Metrics

  • h-index: 28
  • Publications: 136
  • Citations: 2,822

Selected Publications

  • The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase (2024) DOI
  • Reaction Mechanisms of H2S Oxidation by Naphthoquinones (2024) DOI
  • Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate (2023) DOI
  • Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications (2022) DOI
  • Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate (2022) DOI
  • ‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions (2021) DOI
  • Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects (2021) DOI

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