Prabhash Nath Tripathi

High Impact

Postdoctoral researcher

University of Arkansas for Medical Sciences

postdoc

20 h-index 54 pubs 1,638 cited

Research Areas

Alzheimer's disease research and treatments Neuroscience and Neuropharmacology Research Dementia and Cognitive Impairment Research Computational Drug Discovery Methods Pharmacological Effects and Toxicity Studies Phytochemicals and Antioxidant Activities Meta-analysis and systematic reviews Synthesis and biological activity

Links

ORCID Research Group

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OverviewAI-generated summary

Prabhash Nath Tripathi's research focuses on the development of potential inhibitors for acetylcholinesterase (AChE) and amyloid-beta (Aβ) aggregation, key targets in Alzheimer's disease pathology. His work integrates in vitro biochemical assays and in vivo models with computational methods, including the use of Schrodinger software, to validate experimental findings. Tripathi employs analytical techniques such as UV-Vis, FTIR, and NMR for compound characterization.

In collaborative research settings, Tripathi has investigated hybrid ligands for Alzheimer's disease treatment, exploring scaffolds like 1,3,4-oxadiazole, 2-pyridylpiperazine, N-benzylpiperidine, and ferulic acid. These efforts aim to identify compounds with inhibitory activity against cholinesterases, β-secretase-1, amyloid-β, and oxidative stress. The synthesized compounds undergo evaluation through in vitro enzyme and cell-based assays, preclinical in vivo studies, and ex vivo studies using rat brains. Prior to his postdoctoral work, Tripathi gained three years of industrial experience in the synthesis of organic molecules, including carbohydrate-based compounds and biological dyes.

With an h-index of 20 and over 1,638 citations across 54 publications, Tripathi is recognized as a highly cited researcher. His current research group leadership and recent activity indicate an ongoing engagement with his field.

Metrics

h-index: 20
Publications: 54
Citations: 1,638

Selected Publications

Exploring promising pharmaceutical candidates for antiaging (2025) DOI
Therapeutic approaches to age related cognitive decline and neurodegenerative diseases (2025) DOI
Mitochondrial dysfunction and aging (2025) DOI
Neuronal loss and synaptic dysfunction (2025) DOI
Nutrient-Sensing Pathways: Gatekeepers of Longevity (2025) DOI
Intellectual Property Rights in Neuroprotective Biomaterials (2025) DOI