Brian M. Varisco

Professor, Vice Chair for Research

UAMS

faculty

COM | Peds Critical Care

18 h-index 90 pubs 1,221 cited

Research Areas

Emergency and Acute Care Studies Child and Adolescent Health Immune Response and Inflammation Health and Medical Research Impacts Bioinformatics and Genomic Networks Asthma and respiratory diseases Respiratory Support and Mechanisms Neonatal Respiratory Health Research

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Brian Varisco is a Professor and Vice Chair for Research in Pediatric Critical Care at the University of Arkansas for Medical Sciences. His research focuses on understanding the mechanisms of acute respiratory distress syndrome (ARDS) in pediatric patients and identifying biomarkers for risk stratification in critical illness. Varisco has investigated inflammatory and tissue injury markers in pediatric ARDS and the gene-expression signatures associated with multiple organ dysfunction trajectories in critical illness using machine learning. His work also includes studying epithelial transitional states in pulmonary fibrosis and the responses of lung organoids to mechanical stretch. He has published 90 papers, with 1,196 citations, and holds an h-index of 18. Varisco collaborates with researchers at the University of Arkansas for Medical Sciences, including James Williams, A. Edwards, Craig Porter, and Matthew Frazier.

Metrics

h-index: 18
Publications: 90
Citations: 1,221

Selected Publications

Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome (2026) DOI
Novel murine partial tracheal occlusion model with altered respiratory dynamics (2025) DOI
Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2025) DOI
444 scRNA seq analysis of lower respiratory tract immune cells to uncover immuno-endotypes in SA-PARDS (2025) DOI
YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia (2024) DOI
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia (2024) DOI
KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency (2024) DOI
Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2024) DOI
KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency (2024) DOI
Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome (2024) DOI
Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling (2024) DOI
A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase (2023) DOI
Developing a mechanistic understanding of pediatric acute respiratory distress syndrome one cell at a time (2023) DOI
Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency (2023) DOI

Grants & Funding

Chymotrypsin-like Elastase 1 in Lung Development and Disease NIH Principal Investigator
FASEB SRC on The Lung Epithelium in Health and Disease NIH Principal Investigator
Cela1 Mediates Stretch-regulated Elastin Remodeling During Alveolar Septation NIH Principal Investigator