C Cassin

Researcher

Lyon College

unknown

4 h-index 9 pubs 54 cited

Research Areas

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OverviewAI-generated summary

Cassin's research investigates the multifaceted roles of extracellular vesicles (EVs) in disease contexts, with a particular emphasis on developmental biology, gene regulation, and HIV-related complications. Cassin explores the influence of microRNAs and animal genetics on disease, with a focus on cellular communication mechanisms. Recent work has illuminated how EVs derived from specific immune cells (M1 macrophages) can repolarize other macrophages and disrupt skeletal muscle homeostasis under hyperglycemic conditions. Cassin's studies also examine the role of sphingolipids within muscle-derived EVs in controlling muscle stem cell fate during regeneration, as well as the impact of LAM/TREM2+ macrophage-released EVs and extracellular lipid droplets on macrophage phenotype and skeletal muscle cell homeostasis.

Metrics

h-index: 4
Publications: 9
Citations: 54

Selected Publications

LAM/TREM2 <sup>+</sup> macrophages release extracellular vesicles and extracellular lipid droplets which modulate the phenotype of recipient macrophages and homeostasis of skeletal muscle cells (2025) DOI
M1-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis in a hyper-glucose environment (2023) DOI