Christopher E. Nelson Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Assistant Professor

University of Arkansas at Little Rock

faculty

37 h-index 141 pubs 5,693 cited

Research Areas

CRISPR and Genetic Engineering Musculoskeletal pain and rehabilitation Duchenne Muscular Dystrophy Research Cancer Treatment and Pharmacology Immune Response and Inflammation Protein Structure and Dynamics Bioinformatics and Genomic Networks

Links

ORCID Google Scholar Lab Website Research Group

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OverviewAI-generated summary

Christopher E. Nelson's research focuses on the application of genome editing technologies, particularly CRISPR-Cas9, for therapeutic purposes, with a significant emphasis on Duchenne muscular dystrophy (DMD). His work investigates the challenges and optimizations related to the delivery of CRISPR-Cas9 systems, including exploring Cas9-specific immune responses that can impact therapy efficacy in preclinical models. Nelson has also examined the precision and efficacy of RNA-guided DNA integration in muscle loci and contributed to the preclinical development of genome editing strategies for DMD, such as exon skipping.

Beyond gene editing for genetic disorders, Nelson's research interests extend to other areas of biomedical investigation. This includes studies on perfusion and angiogenesis markers in colorectal tumors, exploring different dosing strategies for cancer treatment. His work also encompasses the characterization of biopolymers, such as guar gum, examining their chemical composition and physical properties. Nelson leads a research group and has a publication record that includes work with collaborators from the University of Arkansas at Little Rock and the University of Arkansas at Fayetteville.

Metrics

  • h-index: 37
  • Publications: 141
  • Citations: 5,693

Selected Publications

  • Beyond the Cut: Long-read sequencing reveals complex genomic and transcriptomic changes in AAV-CRISPR therapy for Duchenne Muscular Dystrophy (2025) DOI
  • Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education (2025) DOI
  • Preclinical development of genome editing to treat Duchenne muscular dystrophy by exon skipping (2025) DOI
  • Resistance to Acetyl Coenzyme A Carboxylase (ACCase) Inhibitor in Lolium multiflorum: Effect of Multiple Target-Site Mutations (2024) DOI
  • Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci (2024) DOI
  • Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing (2024) DOI
  • Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci (2024) DOI
  • PINE-TREE enables efficient enrichment of prime-edited hPSCs (2023) DOI
  • Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy (2023) DOI
  • Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies (2022) DOI
  • Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies (2022) DOI

Collaborators

Researchers in the database who share publications

Shilpi Agrawal University of Arkansas at Little Rock 10 shared publications Made Harumi Padmaswari University of Arkansas at Little Rock 6 shared publications Timothy J. Muldoon University of Arkansas at Fayetteville 4 shared publications Abbey L. Stokes University of Arkansas at Little Rock 4 shared publications Gabrielle N. Bulliard University of Arkansas at Little Rock 3 shared publications Abdussaboor Muhammad University of Arkansas at Fayetteville 2 shared publications Kerlin Balza University of Arkansas at Fayetteville 2 shared publications Daniel A. Maxenberger University of Arkansas at Fayetteville 2 shared publications

Similar Researchers

Based on overlapping research topics

Daniel A. Maxenberger University of Arkansas at Fayetteville
CRISPR and Genetic Engineering Musculoskeletal pain and rehabilitation Protein Structure and Dynamics
Good match 3 shared topics
Made Harumi Padmaswari University of Arkansas at Little Rock
CRISPR and Genetic Engineering Musculoskeletal pain and rehabilitation Bioinformatics and Genomic Networks
Good match 3 shared topics
Morgan Reese University of Arkansas at Fayetteville
CRISPR and Genetic Engineering Protein Structure and Dynamics Bioinformatics and Genomic Networks
Related 3 shared topics
Xiaoshen Wang University of Arkansas at Little Rock
CRISPR and Genetic Engineering Immune Response and Inflammation Protein Structure and Dynamics
Related 3 shared topics
Shilpi Agrawal University of Arkansas at Little Rock
CRISPR and Genetic Engineering Protein Structure and Dynamics Bioinformatics and Genomic Networks
Related 3 shared topics
Christopher A. Newton University of Arkansas at Fayetteville
CRISPR and Genetic Engineering Immune Response and Inflammation Bioinformatics and Genomic Networks
Related 3 shared topics