Fang Zheng

Federal Grant PI High Impact

Professor

University of Arkansas for Medical Sciences

faculty

Pharmacology & Toxicology, College of Medicine

23 h-index 63 pubs 2,446 cited

Research Areas

Neuroscience and Neuropharmacology Research Ion Channel Regulation and Function Neurological Disorders and Treatments Pharmacological Effects and Toxicity Studies Gut microbiota and health Cannabis and Cannabinoid Research Receptor Mechanisms and Signaling

Links

ORCID Lab Website UAMS TRI Profile

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Fang Zheng, Professor in Pharmacology & Toxicology at the University of Arkansas for Medical Sciences, studies the mechanisms of neurological disorders and the impact of various compounds on the central nervous system. His research is supported by a $335,471 NIH/National Institute of Neurological Disorders and Stroke grant focused on the role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction. Zheng's work investigates the involvement of ion channels, such as Transient Receptor Potential Canonical (TRPC) channels, in conditions like depression and epilepsy. This includes examining how these channels contribute to hyperexcitability and neuronal cell death in the hippocampus, and the pharmacological differences between various TRPC channel subtypes.

His recent publications explore the effects of venlafaxine on gut microbiota in a mouse model of depression, the self-assembly and stability of Vitamin D3 mediated peptides, and the role of pericyte depolarization in brain capillaries. Zheng also investigates the effects of synthetic cannabinoid receptor agonists on electroencephalographic seizures. With an h-index of 23 and over 2,400 citations across 63 publications, his research network includes collaborators such as Kevin D. Phelan and U Thaung Shwe from the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 23
  • Publications: 63
  • Citations: 2,446

Selected Publications

  • Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes (2025) DOI
  • Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death (2024) DOI
  • Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice (2023) DOI
  • Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons (2023) DOI
  • Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice (2023) DOI
  • Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice (2022) DOI
  • Canonical Transient Receptor Potential Channels as Novel Targets for Antiepileptic Drugs (2022) DOI

Federal Grants 1 $335,471 total

NIH/National Institute of Neurological Disorders and Stroke Contact PI Mar 2023 - Feb 2028

The Role of the Endothelial NPYR1-TRPC3-ET1 Signaling Axis in Neurovascular Coupling Dysfunction

National Institute of Neurological Disorders and Stroke $335,471 R01

Research Interests

I have a long-standing interest in the pathophysiology of epilepsy and stroke. Initially trained as a channel biophysicist, I have also acquired experience and knowledge in molecular biology, biochemistry and pharmacology over the years. This allows me to adopt a multidisciplinary approach in my research. I have a equally long-standing interest in the functional roles of metabotropic glutamate receptor (mGluR), and this interest has led to my recent focus on transient receptor potential (TRPC) channels for the last 6 years. We have demonstrated the unique roles of various TRPC family members in seizure and excitotoxicity.

Grants & Funding

  • The role of TRPC3 channels in neurovascular coupling and peri-infarct depression UAMS College of Medicine Principal Investigator
  • The role of TRPC3 channels in periinfarct depression and stroke UAMS Stroke - Foundation Principal Investigator
  • The Role of Endothelial TRPC3 Channels in Neurovascular Coupling NIH Principal Investigator
  • The role of TRPC3 channels in neurovascular coupling and peri-infarct depression UAMS College of Medicine Principal Investigator
  • ZINC-DEPENDENT APPARENT DESENSITIZATION OF NMDA RECEPTOR NIH Principal Investigator
  • Neuroscience Research Center Core Facility at UAMS NIH Co-Investigator
  • The role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction NIH Principal Investigator
  • MODULATION OF NMDA RECEPTORS BY TYROSINE KINASES NIH Principal Investigator

Collaborators

Researchers in the database who share publications

Kevin D. Phelan University of Arkansas for Medical Sciences 3 shared publications U Thaung Shwe University of Arkansas for Medical Sciences 3 shared publications William E. Fantegrossi University of Arkansas for Medical Sciences 1 shared publication Catheryn D. Wilson University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Fang Liu National Center for Toxicological Research
Neuroscience and Neuropharmacology Research Neurological Disorders and Treatments Pharmacological Effects and Toxicity Studies
Good match 5 shared topics
Glenn D. Newport National Center for Toxicological Research
Neuroscience and Neuropharmacology Research Neurological Disorders and Treatments Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
Becky Divine National Center for Toxicological Research
Neuroscience and Neuropharmacology Research Neurological Disorders and Treatments Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
Leah E. Latham National Center for Toxicological Research
Neuroscience and Neuropharmacology Research Neurological Disorders and Treatments Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
William E. Fantegrossi University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Pharmacological Effects and Toxicity Studies Cannabis and Cannabinoid Research
Good match 4 shared topics
Jaivijay Ramu National Center for Toxicological Research
Neuroscience and Neuropharmacology Research Neurological Disorders and Treatments Pharmacological Effects and Toxicity Studies
Good match 3 shared topics