María Guadalupe Martínez

Researcher

Lyon College

faculty

16 h-index 40 pubs 880 cited

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OverviewAI-generated summary

Dr. María Guadalupe Martínez is actively engaged in research concerning viral infections, with a particular emphasis on the Hepatitis B virus (HBV). Her work encompasses strategies for combating HBV, including targeting covalently closed circular DNA (cccDNA), which is crucial for viral persistence. Recent studies explore the application of gene editing technologies like CRISPR-Cas9 and cytosine base editing to inhibit HBV replication and reduce HBsAg expression. Martínez also employs Cas9-targeted nanopore sequencing to investigate epigenetic heterogeneity in HBV genomes. Additionally, her research interests extend to mosquito-borne diseases, RNA interference and gene delivery, and plant virus research.

Metrics

h-index: 16
Publications: 40
Citations: 880

Selected Publications

Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes (2024) DOI
Helicases DDX5 and DDX17 promote Hepatitis B Virus transcription termination heterogeneity in infected human hepatocytes (2024) DOI