Pankaj Patyal

Researcher

University of Arkansas for Medical Sciences

faculty

7 h-index 34 pubs 230 cited

Research Areas

Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Microbial infections and disease research Diet and metabolism studies Alzheimer's disease research and treatments Pharmacological Effects and Toxicity Studies

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OverviewAI-generated summary

Pankaj Patyal's research investigates the role of mitochondrial dysfunction in neuroinflammation and its connection to Alzheimer's disease pathologies. His work has explored how compounds like valine can improve mitochondrial function and offer protection against oxidative stress. Patyal has also examined the mechanisms by which lipopolysaccharides from *P. gingivalis* induce neuroinflammation, involving oxidative stress and inflammasome activation. His studies include proteomic analyses to understand these processes at a molecular level and have identified pathways, such as Rho/SRF, that modulate mitochondrial functions. Patyal also has experience studying the effects of dietary supplements on plasma protein expression in older adults. His research network includes significant collaborations with Ambika Verma, Gohar M. Azhar, Jeanne Y. Wei, and Robert R. Wolfe at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 7
  • Publications: 34
  • Citations: 230

Selected Publications

  • Biology of Aging I Antisense Oligonucleotide-Mediated SRF Reduction Ameliorates Mitochondrial Dysfunction in Cardiac Aging (2025) DOI
  • P. gingivalis-LPS Activates the Alzheimer’s Disease-Associated Amyloid Secretase Pathway via Caspase-4 (2025) DOI
  • Mitochondrial Dynamics in Aging Heart (2025) DOI
  • Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025) DOI
  • Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025) DOI
  • CARDIAC SPECIFIC OVEREXPRESSION OF SERUM RESPONSE FACTOR ALTERS MITOCHONDRIAL STRUCTURE AND FUNCTION (2024) DOI
  • DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024) DOI
  • DIFFERENTIAL MICRORNAS PROFILING OF MARSHALLESE IN ARKANSAS IS ASSOCIATED WITH CHRONIC DISEASES OF AGING (2024) DOI
  • P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024) DOI
  • The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024) DOI
  • Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024) DOI
  • Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function (2024) DOI
  • Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024) DOI
  • Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function (2024) DOI
  • EAAS AND WHEY PROTEIN MAY IMPROVE PHYSICAL FUNCTION OF OLDER ADULTS INDEPENDENTLY OF GUT MICROBIOME (2023) DOI

Collaborators

Researchers in the database who share publications

Ambika Verma University of Arkansas for Medical Sciences 23 shared publications Gohar M. Azhar University of Arkansas for Medical Sciences 21 shared publications Jeanne Y. Wei University of Arkansas for Medical Sciences 16 shared publications Robert R. Wolfe University of Arkansas for Medical Sciences 3 shared publications Amanda Pangle University of Arkansas for Medical Sciences 3 shared publications Grishma KC University of Arkansas for Medical Sciences 3 shared publications Yingni Che University of Arkansas for Medical Sciences 3 shared publications Jyotsna Shrivastava University of Arkansas for Medical Sciences 3 shared publications

Similar Researchers

Based on overlapping research topics

Grishma KC University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Microbial infections and disease research
Strong match 5 shared topics
Yingni Che University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Microbial infections and disease research
Strong match 5 shared topics
Gohar M. Azhar University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Microbial infections and disease research
Strong match 5 shared topics
Ambika Verma University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Microbial infections and disease research
Strong match 5 shared topics
Sue Griffin University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments
Good match 4 shared topics
Srinivas Ayyadevara University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments
Good match 4 shared topics