Shougang Zhuang Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

PI/Professor

John Brown University

faculty

61 h-index 265 pubs 11,248 cited

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OverviewAI-generated summary

Dr. Shougang Zhuang is a Professor at John Brown University whose research investigates the epigenetic mechanisms underlying kidney and liver diseases, with a particular focus on the roles of histone modifications and DNA methylation. His work explores the therapeutic potential of histone deacetylase inhibitors and other epigenetic modulators in the context of renal and related cancers, chronic kidney disease, and diabetes. Recent studies have examined the histone methyltransferase EZH2 as a therapeutic target for kidney diseases and demonstrated that inhibiting EZH2 can prevent pulmonary fibrosis associated with acute respiratory distress syndrome (ARDS). Zhuang's research also investigates how the histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling pathways.

Metrics

h-index: 61
Publications: 265
Citations: 11,248

Selected Publications

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1 <i>α</i> ‐Mediated Glycolysis in Kidney Fibrosis (2025) DOI
Cardiomyocyte Foxp1‐Specific Deletion Promotes Post‐injury Heart Regeneration via Targeting Usp20‐HIF1ɑ‐Hand1 Signaling Pathway (2025) DOI
CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway (2025) DOI
Obesity-Related Glomerulopathy: Epidemiology, Pathogenesis, and Current Treatments (2024) DOI
<scp>JMJD3</scp> activation contributes to renal protection and regeneration following acute kidney injury in mice (2024) DOI
The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases (2024) DOI
Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage (2023) DOI
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice (2023) DOI
Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway (2023) DOI
Rituximab treatment for refractory nephrotic syndrome in adults: a multicenter retrospective study (2023) DOI
Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization (2023) DOI
Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization (2023) DOI
Protein arginine methyltransferases in renal development, injury, repair, and fibrosis (2023) DOI
A retrospective study of baseline peritoneal transport character and left ventricular hypertrophy in incident peritoneal dialysis patients: interrelationship and prognostic impacts (2022) DOI
Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis (2022) DOI