Brian D. Piccolo

High Impact

Assistant Professor, Tenure Track

University of Arkansas for Medical Sciences

faculty

Peds Pediatrics, College of Medicine

bdpiccolo@uams.edu

24 h-index 89 pubs 1,765 cited

Research Areas

Gut microbiota and health Diet and metabolism studies Child and Adolescent Health Maternal and Perinatal Health Interventions Metabolism and Genetic Disorders Microbial Community Ecology and Physiology Liver Disease Diagnosis and Treatment Health and Medical Research Impacts

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Brian D. Piccolo's research focuses on the complex interplay between diet, the gut microbiome, and metabolic health, particularly in the context of pediatric conditions. His work investigates how dietary components and maternal factors, such as obesity and diet during pregnancy, influence the gut microbial ecology and subsequent health outcomes in offspring. Piccolo has studied the effects of specific dietary interventions, like blueberry supplementation, on ameliorating vascular complications in diabetic models, potentially through mechanisms involving NOX4 and modulation of gut microbes.

Further research by Piccolo explores how dietary fat composition impacts bile acid metabolism and the severity of liver injury in pig models of pediatric non-alcoholic fatty liver disease (NAFLD). His investigations also extend to the influence of iron deficiency on the gut microbiome and its role in enteric infections. Additionally, he examines how exercise training modifies gut and circulating xenometabolites in adults, and how diabetes progression is associated with changes in the ileal transcriptome and gut morphology in rat models. Piccolo leads a research group and collaborates with several researchers at the University of Arkansas for Medical Sciences, including Sree Vamsee Chintapalli and Renny Shang-Lun Lan.

Metrics

h-index: 24
Publications: 89
Citations: 1,765

Selected Publications

Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures (2025) DOI
Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia (2025) DOI
Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues (2024) DOI
Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats (2024) DOI
Physiological response to fetal intravenous lipid emulsion (2024) DOI
Parental cardiorespiratory fitness influences early life energetics and metabolic health (2023) DOI
Exercise training modifies xenometabolites in gut and circulation of lean and obese adults (2023) DOI
Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs (2022) DOI
Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD (2022) DOI
C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice (2022) DOI
Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis (2022) DOI
Associations between maternal obesity and offspring gut microbiome in the first year of life (2022) DOI
Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI (2022) DOI
Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat (2021) DOI
Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy (2021) DOI