Clark Sims
Assistant Staff Scientist
University of Arkansas for Medical Sciences
staff
Pediatrics, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Clark Sims investigates the complex interplay between maternal health, infant development, and the gut microbiome. His research examines how factors such as maternal body composition, diet, and exposure to environmental chemicals like PFAS influence maternal cardiometabolic outcomes and offspring growth. Sims has published work exploring the associations between maternal overweight and obesity and infant gut microbiome composition, as well as how specific nutrients in human milk, like branched-chain amino acids, are linked to infant growth and are affected by maternal body mass index. His studies also consider the impact of different infant feeding practices, including human milk, formula, and soy formula, on skeletal development over time. Sims collaborates with researchers at the University of Arkansas for Medical Sciences, including Aline Andres and Sarah Sobik, contributing to a body of work focused on maternal and child health.
Metrics
- h-index: 15
- Publications: 63
- Citations: 748
Selected Publications
- Circulating short- and medium-chain fatty acids in pregnancy and associations with maternal and infant metabolism, inflammation, and body composition (2026) DOI
- Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality (2026) DOI
- Promoting Breastfeeding Among Latina Women in a Community Pediatric Clinic (2025) DOI
- The Effect of an Exercise Program on Maternal Health and Birth Outcomes in Sedentary Pregnant Participants with Obesity: Randomized Controlled Trial (2025) DOI
- Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis (2025) DOI
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age (2025) DOI
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake (2025) DOI
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy (2025) DOI
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites (2024) DOI
- Exploring the relationship between child temperament, maternal psychiatric symptoms, family environment and infant feeding (2024) DOI
- Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome (2024) DOI
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad (2024) DOI
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life (2024) DOI
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes (2024) DOI
- Maternal FUT2 Secretor Phenotype Is Associated With Human Milk Oligosaccharides and Polyphenol Metabolites Following a Mediterranean Dietary Intervention: A Pilot Study (2024) DOI
Grants & Funding
- Renal microcirculatory failure in a rat pup model of pediatric sepsis American Heart Association (SouthWest Affiliate) Principal Investigator
- Targeting renal perfusion and mitochondrial oxidants in a model of infant sepsis NIH Principal Investigator
Collaborators
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