Abdelrahman Y. Fouda
Associate Professor with tenure
University of Arkansas for Medical Sciences
faculty
Pharmacology & Toxicology, College of Medicine
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Biography and Research Information
OverviewAI-generated summary
Abdelrahman Y. Fouda's research focuses on the molecular mechanisms underlying retinal injury and potential therapeutic interventions. His work investigates the role of arginase enzymes, specifically arginase 1 and arginase 2, in processes such as ischemia-reperfusion injury, proliferative retinopathy, and neovascularization. He has explored how these enzymes influence mitochondrial function, myeloid cell inflammatory responses, and angiogenic repair in the retina.
Fouda's research has been supported by federal grants from the NIH/National Eye Institute, including funding for his work on the role of arginase 1 in retinal ischemia-reperfusion injury and the investigation of retinal neurovascular protection through efferocytosis. His publications examine these mechanisms in the context of conditions like optic neuropathy and diabetic retinopathy. He also collaborates with researchers at the University of Arkansas for Medical Sciences, including Esraa Shosha, Carol Morris, Rami Ahmad Shahror, and Nancy Rusch, contributing to a network of investigations in pharmacology and toxicology.
With a scholarly profile including 86 publications and an h-index of 28, Fouda's work has been recognized as high-impact. His current research interests extend to preclinical investigations of novel treatments, such as pegylated arginase 1, for retinal and brain injuries, and the metabolic function of the retina in disease models.
Metrics
- h-index: 28
- Publications: 86
- Citations: 1,982
Selected Publications
- Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025) DOI
- Myeloid HDAC3 Deletion Protects Against Traumatic Optic Injury (2025) DOI
- Extracellular Vesicle Metabolomics Holds Promise for Adult Axon Regeneration (2025) DOI
- Disrupting the CD47/SIRPα Axis Protects Against Traumatic Optic Neuropathy (2025) DOI
- HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164) (2025) DOI
- Disrupting the CD47/SIRPα Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422) (2025) DOI
- Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy (2025) DOI
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024) DOI
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush (2023) DOI
- Multi-color Flow Cytometry Protocol to Characterize Myeloid Cells in Mouse Retina Research (2023) DOI
- The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis (2022) DOI
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair (2022) DOI
- Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke (2022) DOI
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice (2022) DOI
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers? (2022) DOI
Federal Grants 2 $502,702 total
Grants & Funding
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Role of Arginase 1 in Retinal Ischemia Reperfusion Injury NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
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