Nancy Rusch
Distinguished Professor
University of Arkansas for Medical Sciences
faculty
College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Nancy Rusch is a Distinguished Professor in the College of Medicine at the University of Arkansas for Medical Sciences. Her research focuses on the role of myeloid cells in ischemic retinopathies and the mechanisms of vascular aging. She has investigated how the arginase 1/ornithine decarboxylase pathway and the deletion of myeloid HDAC3 can suppress inflammatory responses to ameliorate retinal ischemic injury.
Rusch's work also explores the impact of drugs on cellular processes, including the attenuation of efferocytosis in endothelial cells by PCSK9, which promotes vascular aging. She has also studied drug-related lymphedema, examining its mechanisms and potential therapies, including the use of Dantrolene to prevent lymphostasis caused by doxorubicin.
Her scholarship metrics include an h-index of 42, with 192 total publications and 4,938 total citations. She is recognized as a high-impact researcher and maintains an active lab website, leading a research group and collaborating with colleagues at the University of Arkansas for Medical Sciences, including Abdelrahman Y. Fouda, Shengyu Mu, Amanda J. Stolarz, and Esraa Shosha.
Metrics
- h-index: 42
- Publications: 192
- Citations: 4,938
Selected Publications
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis (2025) DOI
- The role of efferocytosis in ischemic stroke and insights from retinopathy (2025) DOI
- Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats (2024) DOI
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024) DOI
- The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β‐catenin Signaling via Epigenetic Dysregulation that Enhances Sp1‐β catenin‐p300 Interactions in Hepatocellular Carcinoma (2024) DOI
- SS-31 Attenuates Doxorubicin-induced Cardiomyoblast H9C2 Cell Senescence (2024) DOI
- Abstract 3011: The loss of an orphan nuclear receptor NR2E3 augments Wnt/β-Catenin signaling via epigenetic dysregulation that links to the Sp1-β catenin-p300 interactions in hepatocellular carcinoma (2024) DOI
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024) DOI
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023) DOI
- PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging (2023) DOI
- Mitochondrial proton leak in cardiac aging (2023) DOI
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers? (2022) DOI
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies (2022) DOI
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation (2021) DOI
Grants & Funding
- MicroRNA to decrease vascular CaV1.2 in hypertension NIH Co-Investigator
- AHA-Vascular TRPC3 Channels as Antihypertensive Targets American Heart Association (SouthWest Affiliate) Principal Investigator
- Beta adrenergic receptor-mediated vasodilation of cerebral collateral arteries- Resubmission- Resubmission American Heart Association Principal Investigator
- T32 Campus Match funding Account UAMS College of Medicine Principal Investigator
- Pharmacology Dept GEF Account UAMS College of Medicine Principal Investigator
- Long-term Antihypertensive Therapy by Delivery of the BK Channel Gene to VSMCs NIH Principal Investigator
- Role of mitoBK channels in rat renal cold preservation American Heart Association (SouthWest Affiliate) Principal Investigator
- Role of Cerebrovascular K+ Channels in Hypertension NIH Principal Investigator
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