Brian Storrie
Professor
University of Arkansas for Medical Sciences
faculty
Physiology & Cell Biology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Brian Storrie's research focuses on the structural and functional determinants of thrombus formation, particularly in the context of venous puncture wounds. He investigates the mechanisms by which platelets aggregate and form the vaulted thrombus structure observed at wound sites. His work also examines how factors like the luminal proteoglycan serglycin influence platelet alpha-granule cargo packaging and release. Storrie has explored the utility of deep learning and 3D electron microscopy for analyzing ultrastructural differences in platelets, including those derived from patients with COVID-19.
His laboratory utilizes advanced imaging techniques and computational analysis to quantitatively assess platelet behavior and organelle packing. Storrie also investigates cellular transport and secretion pathways, as demonstrated by his work on a mouse model for Smith-McCort dysplasia, which reveals defects in bone resorption and altered protein glycosylation. He has received funding from the National Institutes of Health (NIH) for his research on thrombus formation.
Metrics
- h-index: 44
- Publications: 180
- Citations: 6,442
Selected Publications
- The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025) DOI
- Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets (2025) DOI
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025) DOI
- Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model (2024) DOI
- Densely Populated Cell and Organelles Segmentation with U-Net Ensembles (2024) DOI
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024) DOI
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis (2024) DOI
- JoVE Video Dataset (2024) DOI
- Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi (2024) DOI
- Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis (2023) DOI
- OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis (2023) DOI
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets (2023) DOI
- A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation (2023) DOI
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis (2023) DOI
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site (2023) DOI
Federal Grants 1 $624,823 total
Resubmission: Structure/Function Determinants of Puncture Wound Thrombus Formation
Research Interests
Research search concentrates on how platelet secretion and aggregation properties structure thrombus formation asd provide structure based therapeutic targets. Much of the research uses volume electronn microscopy as a 3D structural approach to puncture wound thrombi and occlusive clots. Mechanism is approached through the use of mouse genetic knockouts and inhibitory drugs of clinical significance.
Grants & Funding
- 120 kV FEI Electron Microscope and Supporting Sample Preparation Equipment for Biological Microscopy National Science Foundation Principal Investigator
- Platelet Exocytosis and Endocytosis in Thrombosis and Immunity NIH/Nat. Heart, Lung & Blood Institute - Pass Through: University of Kentucky Research Foundation Principal Investigator
- STRUCTURAL ORGANIZATION OF THE MAMMALIAN GOLGI COMPLEX NIH Principal Investigator
- Structural, Functional,and Molecular Characterization of Platelet alpha-Granule Subpopulations American Heart Association (Midwest Affiliate) Principal Investigator
- Platelet Exocytosis and Endocytosis in Thrombosis and Immunity NIH/Nat. Heart, Lung & Blood Institute - Pass Through: University of Kentucky Research Foundation Principal Investigator
- No FP attached UAMS College of Medicine Principal Investigator
- Storrie EM NSF COM Commitment Acct UAMS College of Medicine Principal Investigator
- Mechanisms of Golgi Apparatus Protein Recycling NIH Principal Investigator
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