Irina D. Pokrovskaya

High Impact

Research Associate

University of Arkansas for Medical Sciences

postdoc

25 h-index 82 pubs 1,996 cited

Research Areas

Cellular Transport and Secretion Platelet Disorders and Treatments Metabolism and Genetic Disorders Advanced Neural Network Applications Medical Imaging Techniques and Applications SARS-CoV-2 and COVID-19 Research Molecular Biology Techniques and Applications Protein Structure and Dynamics

Links

ORCID Lab Website

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OverviewAI-generated summary

Irina D. Pokrovskaya's research focuses on cellular biology, with a particular emphasis on the Golgi complex and platelet function. Her work has investigated the role of the conserved oligomeric Golgi (COG) complex in cellular processes, including its impact on Golgi function and the nature of intra-Golgi recycling vesicles. Pokrovskaya has also studied the mechanisms of platelet α-granule cargo packaging and release, examining the influence of proteins like serglycin. Her research has extended to disease-related cellular models, such as those for CDG-II diseases, and has explored the ultrastructural differences in platelets from COVID-19 patients.

Her publication record includes studies on venous puncture wound hemostasis and the structure of thrombi formed by platelet aggregates. Pokrovskaya has also contributed to the development of advanced analytical techniques, including deep learning and 3D ultrastructural analysis for quantitative biological assessments. She has a collaborative research network, with numerous shared publications with colleagues at the University of Arkansas for Medical Sciences, including Brian Storrie, Kelly K. Ball, Vladimir Lupashin, and Sung W. Rhee.

With 82 total publications and an h-index of 25, Pokrovskaya is recognized as a highly cited researcher. Her work leverages sophisticated imaging and computational methods to understand complex cellular dynamics and their implications for health and disease.

Metrics

h-index: 25
Publications: 82
Citations: 1,996

Selected Publications

The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025) DOI
Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets (2025) DOI
Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025) DOI
Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i> ‐Glycosylation (2025) DOI
Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model (2024) DOI
Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation (2024) DOI
Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024) DOI
Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis (2024) DOI
JoVE Video Dataset (2024) DOI
Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi (2024) DOI
Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis (2023) DOI
Essential role of the conserved oligomeric Golgi complex in <i>Toxoplasma gondii</i> (2023) DOI
OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis (2023) DOI
Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets (2023) DOI
Syntaxin‐5's flexibility in <scp>SNARE</scp> pairing supports Golgi functions (2023) DOI