Fen Xia

Federal Grant PI High Impact

Department Chairperson

University of Arkansas for Medical Sciences

faculty

Department Chairs, College of Medicine

40 h-index 176 pubs 6,424 cited

Research Areas

DNA Repair Mechanisms Cancer Treatment and Pharmacology Sirtuins and Resveratrol in Medicine Nanoparticles: synthesis and applications Advanced Neural Network Applications Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Health Sciences Research and Education

Links

Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Fen Xia's research focuses on investigating mechanisms of DNA damage response and repair, particularly in the context of cancer treatment and the prevention of treatment-related side effects. This work includes studying the role of specific proteins, such as Sirtuin 2 (SIRT2), in regulating these processes. Xia has received funding from the NIH/National Cancer Institute for research into the novel role of Sirtuin 2 in the regulation of transcription-associated DNA damage repair. Their publications also explore how interventions like nicotinamide riboside can alleviate cisplatin-induced peripheral neuropathy through SIRT2 activation, and how targeting DNA damage response pathways can enhance the therapeutic index of cisplatin-based cancer treatments.

Beyond molecular mechanisms, Xia's research interests extend to other areas as indicated by their diverse publication record. These include work on deepFake video detection using transformer models, the development of antioxidant copper pastes for flexible printed electronics, and the preparation of novel cement-based materials. Xia's scholarly contributions are reflected in their h-index of 40 and over 6,400 citations across 176 publications, designating them as a highly cited researcher.

Metrics

h-index: 40
Publications: 176
Citations: 6,424

Selected Publications

Spatially Fractionated Radiotherapy GRID for Bulky Tumor: A Large Single Institution Experience (2024) DOI
A Prospective Study Measuring Resident and Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation in Radiation Oncology Residency (2023) DOI
A Prospective Study Measuring Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation (2023) DOI
Analysis of Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Target Volume Delineation (2022) DOI
Measuring resident/faculty contour concordance as a potential tool for quantitative assessment of residents' performance in target volume delineation: a feasibility study (2022) DOI
A phantom-based study and clinical implementation of brainlab’s treatment planning system for radiosurgical treatments of arteriovenous malformations (2022) DOI
Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation (2022) DOI
#Brachytherapy: Physicians As Influencers on Instagram (2022) DOI
A dosimetric comparative analysis of Brainlab elements and Eclipse RapidArc for spine SBRT treatment planning (2022) DOI
Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment (2021) DOI
SIRT2 promotes murine melanoma progression through natural killer cell inhibition (2021) DOI
Abstract IA-024: Sirt2: A tumor suppressor or promotor? (2021) DOI

Federal Grants 1 $326,880 total

NIH/National Cancer Institute Contact PI Apr 2020 - Mar 2026

The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair

National Cancer Institute $326,880 R01

Grants & Funding

A Prospective Trial of Stereotactic Adaptive Radiation Therapy for Borderline Resectable/Locally Advanced Pancreatic Cancer: An Individualized Approach to Minimizing Gastrointestinal Toxicity (ARTIA-Pancreas) Varian Medical Systems Principal Investigator
Novel functions of Pyruvate kinase M2 in DNA double-strand break repair NIH/NCI Principal Investigator
The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair NIH/Nat. Cancer Institute Principal Investigator
GSK3b mediates radiation-induced cytotoxicity in hippocampal neurons NIH Principal Investigator
Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
GSK3b mediates radiation-induced cytotoxicity in hippocampal neurons NIH Principal Investigator
The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair NIH/Nat. Cancer Institute Principal Investigator