Kartik Balachandran Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Federal Grant PI High Impact

Professor

University of Arkansas at Fayetteville

faculty

26 h-index 88 pubs 2,727 cited

Research Areas

Cardiac Valve Diseases and Treatments SARS-CoV-2 and COVID-19 Research Traumatic Brain Injury Research Microphysiological Systems Tissue Engineering and Regenerative Medicine Neuroinflammation and Neurodegeneration Mechanisms COVID-19 Clinical Research Studies

Links

ORCID Lab Website Research Group

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Kartik Balachandran's research investigates complex biological systems, with a focus on microphysiological systems and their application to disease modeling. His work includes the development and utilization of "organ-on-a-chip" technologies to study conditions such as calcific aortic valve disease and SARS-CoV-2-mediated valve disease. He has received federal funding for these projects, including a $436,642 award from the NIH/National Institute of Allergy and Infectious Diseases for research on ACE2 SARS-CoV-2-mediated valve disease in a microphysiological tissue-chip model. Balachandran also explores the impact of traumatic brain injury on neurological function, examining changes in the cortical transcriptome and proteome, as well as blood-brain barrier integrity and astrocyte reactivity.

His research group has also investigated the effects of mechanical strain on endothelial progenitor cell differentiation and developed a nasal airway-on-a-chip model to assess epithelial cell maturation. Balachandran's scholarship metrics include an h-index of 26 and over 2,700 citations across 88 publications. He actively collaborates with researchers at the University of Arkansas at Fayetteville, including Ishita Tandon, Gustavo Vaca-Diez, Alan E. Woessner, and Patrick Kuczwara, with whom he has co-authored multiple publications.

Metrics

h-index: 26
Publications: 88
Citations: 2,727

Selected Publications

Characterizing Piezoelectric‐Blended Polydimethylsiloxane for Use as a Mechanoelectrical Responsive Cell Culture Substrate (2025) DOI
Elucidating the mechanosensitive pathways of physiological and pathological strain on valve cells in a novel human valve-on-chip system (2025) DOI
The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types (2024) DOI
The effect of traumatic injuries on the nervous system (2024) DOI
Contributors (2024) DOI
A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression (2024) DOI
The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types (2024) DOI
A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression (2023) DOI
Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i> (2022) DOI
Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation (2022) DOI
Aortic valve cell microenvironment: Considerations for developing a valve-on-chip (2021) DOI
Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves (2021) DOI
Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury (2021) DOI
Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease (2021) DOI