Neriman Gökden

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

Pathology, College of Medicine

29 h-index 94 pubs 2,853 cited

Research Areas

Links

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OverviewAI-generated summary

Neriman Gökden's research focuses on understanding the fundamental mechanisms of cancer development and its clinical implications. Her work investigates the stem cell origin of cancer, exploring how oncogenesis can recapitulate processes seen in embryogenesis. This line of inquiry extends to the clinical applications of this theory, particularly concerning cellular metabolism and the development of anti-cancer metabolomics strategies. Gökden also examines the role of cancer immunity and immunotherapy within this framework.

Her research also delves into specific areas of pathology, including the study of distal tubular hyperplasia and germ cell tumors of the testis, with an emphasis on identifying and understanding lethal subtypes of these cancers. Additionally, Gökden has been involved in studies utilizing advanced imaging and artificial intelligence for cancer detection, such as the external validation of an AI algorithm for prostate cancer detection using biparametric MRI. Her work extends to transplantation immunology, investigating the effects of cold storage on rat kidney allografts and the role of the immunoproteasome in these processes.

Gökden holds a Professor position in the Department of Pathology at the University of Arkansas for Medical Sciences. She has authored 94 publications, with an h-index of 29 and over 2,853 citations. She leads a research group and collaborates with several colleagues at her institution, including Ahmet Murat Aydın, Timothy Langford, Sunny Singh, and Manisha Singh, with whom she shares multiple publications.

Metrics

h-index: 29
Publications: 94
Citations: 2,853

Selected Publications

Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys (2025) DOI
The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025) DOI
Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer (2024) DOI
Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function (2024) DOI
Stem Cell Theory of Cancer: Clinical Implications for Cellular Metabolism and Anti-Cancer Metabolomics (2024) DOI
Identification of a panel of microRNA biomarkers for the management of patients with refractory germ cell tumor of the testis. (2024) DOI
I Am in a Crystal Bind! A Case that Gave Us Ulcers (2023) DOI
Giant left pheochromocytoma with vascular anomalies and pelvic horseshoe kidney: a case report (2023) DOI
Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care (2023) DOI
Stem Cell Origin of Cancer: Clinical Implications for Cancer Immunity and Immunotherapy (2023) DOI
Membranous Nephropathy- over the counter? NELL yes! (2023) DOI
Stem Cell Origin of Cancer: Implications of Oncogenesis Recapitulating Embryogenesis in Cancer Care (2023) DOI
Membranous Nephropathy Over the Counter? NELL Yes! (2022) DOI
Incidental, Solitary, and Unilateral Adrenal Metastasis as the Initial Manifestation of Lung Adenocarcinoma (2022) DOI
Granulomatosis with polyangiitis and renal cell cancer: A sinister association - case report and review of literature (2021) DOI

Research Interests

I have had many collaborations with researchers in other departments, especially researchers in the Nephrology and Pharmacology/Toxicology divisions at UAMS and other institutions at both nationally and internationally. In such cases, I contributed to the funded basic research by providing diagnostic evaluation and clinical skills, providing guidance for histology, immunohistochemistry and electron microscopy use in research projects by taking full responsibility for ensuring rigorous quality control and quality assurance on all samples processed by the histology core laboratory. The majority of my research relates to genitourinary and renal pathology. - I worked on kidney and prostate cancer in collaboration with Dr. Graham Greene and Dr. Rabi Madi in Urology Department at UAMS, and Dr. Jesse McKenney at Stanford University, CA and Dr. Kiril Trpkov at University of Calgary, Canada. I have been awarded one of our departmental research grants for one of my own projects. - In renal pathology, I work on myeloma-related kidney diseases because of the large number of kidney biopsies coming from myeloma patients at the Myeloma Institute for Research and Therapy. My completed projects as PI were in collaboration with Dr. Bart Barlogie at UAMS, Dr. Helen Liapis at Washington University in Saint Louis, MO, and Dr. Patrick Walker at Nephropath Laboratory in Little Rock, AR. They included exploring morphologic heterogeneity of light chain deposition disease and cast nephropathy in a large series of cases. Our results have been published in prestigious, high impact journals. - In collaboration with the program project grant in our nephrology division which was funded by NIH and VA grants, work on kidney lipoprotein lipase, the role of renal tubule triglyceride accumulation in cisplatin-mediated acute renal failure, and the renal survival pathway in ischemia/reperfusion injury has been completed. Our results were published in several prestigious journals. - I have a long standing collaboration with Dr. Phillip Mayeux in the Pharmacology/Toxicology Department. Our completed projects included looking into hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury, the effects of resveratrol for improving renal microcirculation, protecting the tubular epithelium, and prolonging survival in a mouse model of sepsis-induced acute kidney injury. We also looked into the protective effects of Actinonin in the renal microcirculation during sepsis. Our collaborations were fruitful and several articles were published, one of which made the cover of the journal Kidney International.