Nirjal Mainali

Researcher

University of Arkansas for Medical Sciences

faculty

8 h-index 13 pubs 158 cited

Research Areas

Neuroinflammation and Neurodegeneration Mechanisms Protein Structure and Dynamics Mitochondrial Function and Pathology Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Metabolism and Genetic Disorders Cardiovascular Function and Risk Factors

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OverviewAI-generated summary

Nirjal Mainali's research investigates the molecular mechanisms underlying aging and age-associated diseases, with a particular focus on protein aggregation and cellular stress pathways. His work has explored the role of mitochondria in aging and the physiological consequences of endoplasmic reticulum stress in conditions such as myocardial infarction, affecting both the heart and brain. Mainali has examined how specific compounds, like thiadiazolidinone analogs and ezetimibe, can inhibit protein aggregation pathology in neurodegenerative models and extend lifespan in model organisms. He has also contributed to identifying novel drug targets for Alzheimer's disease by analyzing protein interactions within brain amyloid aggregates. His research network includes collaborators from the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications. Mainali has published 13 papers, accumulating 158 citations and an h-index of 8.

Metrics

  • h-index: 8
  • Publications: 13
  • Citations: 158

Selected Publications

  • Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025) DOI
  • Strong reduction of cryoprotectant toxicity by stress response induction (2024) DOI
  • Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024) DOI
  • Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity (2024) DOI
  • Leave-one-out-analysis (LOOA): web-based tool to predict influential proteins and interactions in aggregate-crosslinking proteomic data (2024) DOI
  • Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023) DOI
  • Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023) DOI
  • Protein homeostasis in the aged and diseased heart (2023) DOI
  • Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases (2022) DOI

Collaborators

Researchers in the database who share publications

Robert J. Shmookler Reis University of Arkansas for Medical Sciences 10 shared publications Srinivas Ayyadevara University of Arkansas for Medical Sciences 10 shared publications Meenakshisundaram Balasubramaniam University of Arkansas for Medical Sciences 7 shared publications Akshatha Ganne University of Arkansas for Medical Sciences 5 shared publications Sonu Pahal University of Arkansas for Medical Sciences 4 shared publications Ramani Atluri University of Arkansas for Medical Sciences 2 shared publications Jawahar L. Mehta University of Arkansas for Medical Sciences 2 shared publications Anna Mazur University of Arkansas for Medical Sciences 2 shared publications

Similar Researchers

Based on overlapping research topics

Srinivas Ayyadevara University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms Protein Structure and Dynamics Mitochondrial Function and Pathology
Good match 5 shared topics
James Cordova University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms Protein Structure and Dynamics Mitochondrial Function and Pathology
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Sue Griffin University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms Protein Structure and Dynamics Mitochondrial Function and Pathology
Good match 4 shared topics
T.M. do Nascimento Garcia University of Arkansas – Fort Smith
Neuroinflammation and Neurodegeneration Mechanisms Protein Structure and Dynamics Cardiovascular Function and Risk Factors
Good match 3 shared topics
Peter DelNero University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms Protein Structure and Dynamics Alzheimer's disease research and treatments
Good match 3 shared topics
Gohar M. Azhar University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments
Good match 4 shared topics