Randal S. Shelton

Researcher

University of Arkansas for Medical Sciences

faculty

4 h-index 19 pubs 65 cited

Research Areas

Cancer Immunotherapy and Biomarkers Pancreatic and Hepatic Oncology Research Nanoparticles: synthesis and applications Immune Response and Inflammation Carcinogens and Genotoxicity Assessment Viral Infections and Vectors DNA Repair Mechanisms

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OverviewAI-generated summary

Randal S. Shelton's research investigates strategies to enhance the effectiveness of cancer therapies, particularly focusing on modulating the tumor microenvironment. His work includes studies on oncolytic viruses, such as the Jurona virus, in combination with immune checkpoint blockade to improve treatment outcomes in hepatocellular carcinoma and pancreatic cancer models. Shelton also explores targeting the tumor stroma to increase resectability in pancreatic cancer and reprogramming the tumor microenvironment through alloantigen-expressing virotherapy to elicit tumor rejection and improve immunotherapy response.

Additional research interests include the role of Endonuclease G in cellular apoptosis during kidney injury and the comprehensive risk assessment of nanomaterials, specifically carbon nanotubes, for agricultural applications. Shelton has published 19 papers, with an h-index of 4 and 65 total citations. He collaborates with researchers Alexei G. Basnakian, Steven R. Post, Martin J. Cannon, and Mulu Z. Tesfay.

Metrics

h-index: 4
Publications: 19
Citations: 65

Selected Publications

Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025) DOI
Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2025) DOI
Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2025) DOI
Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024) DOI
Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models (2024) DOI
Endonuclease G (EndoG) Inhibits DNase I-Mediated Apoptosis and DNA Repair in Kidney Tubular Epithelial Cells During Cisplatin Injury (2023) DOI
Comprehensive Risk Assessment of Carbon Nanotubes Used for Agricultural Applications (2022) DOI
PHF19 inhibition as a therapeutic target in multiple myeloma (2021) DOI