Rosalia C.M. Simmen

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

32 h-index 97 pubs 2,981 cited

Research Areas

Links

ORCID Lab Website

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OverviewAI-generated summary

Rosalia C.M. Simmen's research focuses on the intersection of diet, metabolism, and various health conditions, including obesity, hepatic steatosis, and cancer. Her work investigates the molecular mechanisms underlying these conditions, particularly the role of specific enzymes and transcription factors like Malic Enzyme 1 (ME1) and Krüppel-like Factors (KLFs). She has published studies examining how ME1 promotes adiposity and hepatic steatosis, and how KLF9 and KLF13 influence oncogenesis, with specific attention to KLF9's role in suppressing hepatocellular carcinoma development in the context of a high-fat diet.

Simmen's research also extends to reproductive health, with investigations into endometriosis and its association with tumors, as well as the co-existence of diabetes and endometriosis in women. Her work has explored how genetic factors and dietary influences, such as high-fat diets, can modify endometriosis development. Additionally, her publications include studies on the heritability of serum insulin-like growth factor I concentration and its correlation with weight and height in livestock, indicating a broad interest in metabolic and genetic influences on physiological traits.

Her scholarly contributions are reflected in a h-index of 32 and nearly 3,000 citations across 97 publications. Simmen collaborates with several researchers at the University of Arkansas for Medical Sciences, including Frank A. Simmen, Charles M. Quick, Garrett L. Graham, and Maria Theresa E. Montales, with whom she shares multiple publications. She maintains an active laboratory website.

Metrics

h-index: 32
Publications: 97
Citations: 2,981

Selected Publications

Transcriptional drivers and endocrine disorders (2025) DOI
Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025) DOI
Endometriosis and Endometriosis-Associated Tumors (2025) DOI
Heritability and Correlation Estimates for Serum Insulin-like Growth Factor I Concentration, Weight, Weight Gain, and Height in Angus Beef Cattle in a Long-Term Divergent Selection Study for Serum Insulin-like Growth Factor I (1989 to 2017) (2024) DOI
Endometriosis and Endometriosis-Associated Tumors (2024) DOI
Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023) DOI
Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023) DOI
A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression (2023) DOI
Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022) DOI
Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021) DOI
Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021) DOI
Co-Morbidity of Type 1 Diabetes Promotes Endometriosis Status-A Pilot Study (2021) DOI