W. Sue T. Griffin
Professor
University of Arkansas for Medical Sciences
faculty
Geriatrics, College of Medicine
Research Areas
Is this your profile? Verify and claim your profile
Biography and Research Information
OverviewAI-generated summary
W. Sue T. Griffin's research focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease and glioblastoma. Griffin investigates the role of specific molecular pathways, such as those involving the proinflammatory cytokine IL-1β, protein aggregates, and the APOEε4 genotype, in the pathogenesis of these conditions. Her work also explores the potential of small molecules to rescue cellular dysfunctions, including lysosomal autophagic failure, which are implicated in Alzheimer's disease. Additionally, Griffin has been involved in research examining the Protein C pathway in mitigating radiation-induced endothelial and vascular dysfunction, and has received federal funding for studies related to cancer and developing entrepreneurial technologies.
Griffin's scholarly contributions are reflected in a h-index of 65 and over 17,000 citations across 173 publications. She has served as Principal Investigator (PI) on multiple NIH grants, including awards totaling over $1.2 million for research on neuroinflammation, protein aggregates, ApoE4 drug targeting, and autophagy rescue, as well as cancer and developing entrepreneurial technologies. Griffin is a designated high-impact researcher and leads an active research group at the University of Arkansas for Medical Sciences, collaborating with several colleagues within the institution.
Metrics
- h-index: 65
- Publications: 173
- Citations: 17,368
Selected Publications
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026) DOI
- When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025) DOI
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025) DOI
- Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025) DOI
- Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025) DOI
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023) DOI
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease (2021) DOI
- Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer’s Disease (2021) DOI
Federal Grants 3 $1,282,027 total
Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue
The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
Grants & Funding
- GENE EXPRESSION IN BRAIN CELLS IN AIDS NIH Principal Investigator
- Early Events in Alzheimer Pathogenesis NIH Principal Investigator
- CYTOKINES, NEURODEGENERATION AND DOWN'S SYNDROME NIH Principal Investigator
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH/Nat. Inst. on Aging Principal Investigator
- BRAIN DEVELOPMENT AND GRAFT VERSUS HOST DISEASE NIH Principal Investigator
- Compromised function of a glial glucose transporter in aging and Alzheimer's disease NIH Co-Investigator
- Amyloid Precursor Protein and Ubiquitination NIH/Nat. Inst. on Aging Co-Investigator
- Center for Translational Neuroscience NIH Co-Investigator
Collaborators
Researchers in the database who share publications
Similar Researchers
Based on overlapping research topics