Lu Huang profile photo

Lu Huang

Federal Grant PI High Impact

Assistant Professor

University of Arkansas for Medical Sciences

faculty

Microbiology & Immunology, College of Medicine

42 h-index 180 pubs 6,047 cited

Research Areas

Macrophage metabolism in diabetes and tuberculosis comorbidity Ontogeny and metabolism of lung alveolar macrophages in tuberculosis Single-cell spatial-temporal understanding of the role of macrophage subsets in maintenance of lesion biology and local Mycobacterium tuberculosis infection outcome Immune Response and Inflammation Microbial infections and disease research Diet and metabolism studies Phytochemicals and Antioxidant Activities Genomics and Phylogenetic Studies

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Lu Huang's research focuses on understanding host-pathogen interactions, particularly in the context of tuberculosis and macrophage biology. As a Principal Investigator on multiple NIH grants, Huang has secured substantial funding to investigate the ontogeny and metabolism of lung alveolar macrophages in tuberculosis, the role of macrophage subsets in maintaining lesion biology and infection outcomes, and the intricate relationship between macrophage metabolism, diabetes, and tuberculosis comorbidity. This work utilizes advanced techniques such as single-cell analysis and lattice light sheet microscopy to reveal dynamic cellular processes and spatial-temporal understanding of disease progression.

Beyond tuberculosis, Huang's research portfolio extends to exploring signaling pathways and metabolic reprogramming, with publications examining PI3K signaling's role in metabolic reprogramming and potential therapeutic strategies for Non-Alcoholic Fatty Liver Disease (NAFLD) involving CYP2E1 and flavonoids. The researcher also investigates immunomodulatory peptides and has contributed to studies on plant genomics and gene editing systems for crop improvement. Huang's scholarly contributions are reflected in a high h-index of 42 and over 6,000 citations across 180 publications, underscoring a significant impact in the field.

Metrics

  • h-index: 42
  • Publications: 180
  • Citations: 6,047

Selected Publications

  • Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics (2025) DOI
  • Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer (2024) DOI
  • Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024) DOI
  • SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome (2024) DOI
  • BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2024) DOI
  • Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection (2022) DOI
  • Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung (2021) DOI
  • Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology (2021) DOI

Federal Grants 4 $1,377,214 total

NIH/National Institute of Allergy and Infectious Diseases Contact PI Aug 2025 - Jul 2027

Single-cell spatial-temporal understanding of the role of macrophage subsets in maintenance of lesion biology and local Mycobacterium tuberculosis infection outcome

National Institute of Allergy and Infectious Diseases $450,500 R21
NIH/National Institute of Allergy and Infectious Diseases Contact PI Sep 2024 - Sep 2025

Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens

National Institute of Allergy and Infectious Diseases $1 R01
NIH/National Institute of Allergy and Infectious Diseases Contact PI Aug 2024 - Jul 2029

Ontogeny and metabolism of lung alveolar macrophages in tuberculosis

National Institute of Allergy and Infectious Diseases $733,424 R01
NIH/National Institute of Allergy and Infectious Diseases Contact PI Aug 2023 - Jul 2026

Macrophage metabolism in diabetes and tuberculosis comorbidity

National Institute of Allergy and Infectious Diseases $193,289 R21

Grants & Funding

  • ECU sub to UAMS NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: East Carolina University Principal Investigator
  • Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Macrophage metabolism in diabetes and tuberculosis comorbidity NIH/National Institutes of Health Principal Investigator
  • Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract US Department of Agriculture - Pass Through: University of Arkansas at Pine Bluff Principal Investigator
  • Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Deciphering trained immuity in lung resident macrophages to combat tuberculosis American Lung Association Principal Investigator

Collaborators

Researchers in the database who share publications

Lin-Xi Li University of Arkansas for Medical Sciences 4 shared publications J. Tucker Andrews University of Arkansas for Medical Sciences 4 shared publications Shengyu Mu University of Arkansas for Medical Sciences 3 shared publications Zijing Zhang University of Arkansas for Medical Sciences 3 shared publications Katherine Deck University of Arkansas for Medical Sciences 2 shared publications Yunping Guo University of Arkansas for Medical Sciences 2 shared publications Christoph Mora University of Arkansas for Medical Sciences 2 shared publications Charles M. Quick University of Arkansas for Medical Sciences 1 shared publication

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