Katherine Deck

Federal Grant PI

Researcher

University of Arkansas for Medical Sciences

faculty

4 h-index 28 pubs 89 cited

Research Areas

Blood Pressure and Hypertension Studies Immune Response and Inflammation Immune Cell Function and Interaction Cardiovascular Function and Risk Factors T-cell and B-cell Immunology Extracellular Vesicles in Disease

Links

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OverviewAI-generated summary

Katherine Deck's research program investigates the intersection of immunity and hypertension. Her work has explored the role of T cells, specifically CD8+ T cells, in the development and maintenance of high blood pressure, including salt-sensitive hypertension. Deck has published studies detailing how specific immune pathways, such as the IFNγ-PDL1 pathway and P2X7 receptor activation, contribute to hypertension by influencing immune cell interactions and promoting inflammation.

Her recent publications also examine the contribution of IL-10 to macrophage-to-myofibroblast transition, which promotes chronic fibrosis in the failing heart. Additionally, Deck's research considers the utility of extracellular vesicles (uEVs) as a tool for examining renal epithelial cells. Her federal grant funding from the NIH/National Heart Lung and Blood Institute supports her investigation into how kidney-resident memory CD8+ T cells promote hypertension and influence salt sensitivity. Deck collaborates with researchers at the University of Arkansas for Medical Sciences, including Christoph Mora, Shengyu Mu, Yunping Guo, and Tonya Rafferty, with whom she has co-authored numerous publications.

Metrics

  • h-index: 4
  • Publications: 28
  • Citations: 89

Selected Publications

  • IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287 (2025) DOI
  • Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288 (2025) DOI
  • Energy Overload: ATP-P2X7-Mediated T Cell Activation in Obesity-Induced Type 2 Diabetes 9286 (2025) DOI
  • Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension (2025) DOI
  • Uncovering immune pathways for therapeutic targeting of hypertension (2025) DOI
  • Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025) DOI
  • Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025) DOI
  • Establishment of resident memory T cells anchors hypertension in the kidney (2025) DOI
  • T Cells Drive Kidney Memory for Hypertension (2024) DOI
  • Abstract P200: Immune memory contributes to chronic hypertension recurrence (2024) DOI
  • Abstract P335: An innate immune component in hypertension-induced cardiac dysfunction Christoph Mora, Katherine Deck, Yunmeng Liu, Lance Benson, Tonya Rafferty, & Shengyu Mu (2024) DOI
  • P227 MACROPHAGE TO MYOFIBROBLAST TRANSITION IN THE DEVELOPMENT OF DIASTOLIC DYSFUNCTION (2024) DOI
  • O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION (2024) DOI
  • Kidney resident memory CD8 T cells mediate recurrence of salt-sensitive hypertension (2024) DOI
  • Macrophage to Myofibroblast Transition Promotes Hypertension-Induced Cardiac Diastolic Dysfunction (2024) DOI

Federal Grants 1 $39,509 total

NIH/National Heart Lung and Blood Institute Contact PI Sep 2024 - Sep 2026

Kidney-resident memory CD8+ T cells promote hypertension and memorize salt sensitivity.

National Heart Lung and Blood Institute $39,509 F31

Collaborators

Researchers in the database who share publications

Christoph Mora University of Arkansas for Medical Sciences 27 shared publications Shengyu Mu University of Arkansas for Medical Sciences 23 shared publications Yunping Guo University of Arkansas for Medical Sciences 15 shared publications Tonya Rafferty University of Arkansas for Medical Sciences 14 shared publications Yunmeng Liu University of Arkansas for Medical Sciences 10 shared publications Pamela I. Rogers University of Arkansas for Medical Sciences 9 shared publications Shuoqiu Deng University of Arkansas for Medical Sciences 9 shared publications Pamela Rogers University of Arkansas for Medical Sciences 5 shared publications

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Yunping Guo University of Arkansas for Medical Sciences
Blood Pressure and Hypertension Studies Immune Response and Inflammation Immune Cell Function and Interaction
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Shengyu Mu University of Arkansas for Medical Sciences
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Blood Pressure and Hypertension Studies Immune Response and Inflammation Immune Cell Function and Interaction
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Lin-Xi Li University of Arkansas for Medical Sciences
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J. Tucker Andrews University of Arkansas for Medical Sciences
Immune Response and Inflammation Immune Cell Function and Interaction Cardiovascular Function and Risk Factors
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