Srinivas Ayyadevara Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

30 h-index 89 pubs 5,143 cited

Research Areas

Neuroscience and Neuropharmacology Research Alzheimer's disease research and treatments Mitochondrial Function and Pathology Protein Structure and Dynamics Neuroinflammation and Neurodegeneration Mechanisms Pharmacological Effects and Toxicity Studies Metabolism and Genetic Disorders

Links

ORCID Lab Website UAMS TRI Profile

Edit your profile

OverviewAI-generated summary

Srinivas Ayyadevara's research focuses on understanding the molecular mechanisms underlying neurodegenerative diseases and aging. His work investigates the role of protein aggregation, cellular stress pathways, and mitochondrial dysfunction in the progression of age-associated diseases, including Alzheimer's disease and myocardial infarction. Ayyadevara has published research on glial fibrillary acidic protein as a biomarker and therapeutic target for Alzheimer's disease, and has identified intrinsically disordered proteins within aggregate proteomes that serve as indicators of neurodegeneration. His studies also explore the composition of protein aggregates, noting the entrapment of RNA and DNA within these structures and potential rescue mechanisms.

Further investigations by Ayyadevara include the development of novel therapeutic agents for Alzheimer's disease, such as hydroxybenzylamine-deoxyvasicinone hybrids targeting anticholinesterase activity. He has also examined small molecules capable of rescuing lysosomal autophagic failure associated with ApoE4 in Alzheimer's disease models and the efficacy of thiadiazolidinone analogs in inhibiting aggregation-mediated pathology and extending lifespan in model organisms. His federally funded work, supported by a $374,971 grant from the NIH/National Institute on Aging, aims to infer common pathways underlying neurodegeneration and other age-progressive diseases. Ayyadevara collaborates extensively with researchers at the University of Arkansas for Medical Sciences, including Robert J. Shmookler Reis and Meenakshisundaram Balasubramaniam.

Metrics

h-index: 30
Publications: 89
Citations: 5,143

Selected Publications

The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026) DOI
Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation (2025) DOI
When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025) DOI
The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025) DOI
Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025) DOI
Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024) DOI
Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity (2024) DOI
Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024) DOI
Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023) DOI
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023) DOI
Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023) DOI
Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes (2023) DOI
Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes (2023) DOI
Protein homeostasis in the aged and diseased heart (2023) DOI
Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases (2022) DOI