Frank A. Simmen Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

54 h-index 208 pubs 7,524 cited

Research Areas

Diet and metabolism studies Cancer-related molecular mechanisms research Metabolism and Genetic Disorders Molecular Biology Techniques and Applications Immune Response and Inflammation Obesity

Links

ORCID Google Scholar Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Frank A. Simmen's research focuses on the molecular mechanisms underlying metabolic diseases and oncogenesis, with a particular emphasis on the roles of specific transcription factors and enzymes. His recent work investigates how Malic Enzyme 1 (ME1) contributes to obesity and hepatic steatosis, influencing circulating insulin and leptin levels in mouse models. He also studies the function of Krüppel-like Factors (KLFs), specifically KLF9 and KLF13, examining their dual roles as repressors and activators in cancer development. His research has demonstrated that KLF9 can suppress hepatocellular carcinoma progression by mitigating oxidative stress and inflammation in mice on high-fat diets.

Metrics

  • h-index: 54
  • Publications: 208
  • Citations: 7,524

Selected Publications

  • Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025) DOI
  • Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023) DOI
  • Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023) DOI
  • Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022) DOI
  • Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021) DOI
  • Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021) DOI

Collaborators

Researchers in the database who share publications

Rosalia C.M. Simmen University of Arkansas for Medical Sciences 6 shared publications Maria Theresa E. Montales University of Arkansas for Medical Sciences 2 shared publications Lin-Xi Li University of Arkansas for Medical Sciences 1 shared publication Richard Jon Ward Harding University Main Campus 1 shared publication

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Maria Theresa E. Montales University of Arkansas for Medical Sciences
Diet and metabolism studies Cancer-related molecular mechanisms research Metabolism and Genetic Disorders
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Mulu Tesfay University of Arkansas for Medical Sciences
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Diet and metabolism studies Cancer-related molecular mechanisms research Metabolism and Genetic Disorders
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Isabelle Racine Miousse University of Arkansas for Medical Sciences
Diet and metabolism studies Cancer-related molecular mechanisms research Metabolism and Genetic Disorders
Good match 5 shared topics