Kevin A. Murach Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Federal Grant PI High Impact

Researcher

University of Arkansas at Fayetteville

faculty

35 h-index 145 pubs 3,569 cited

Research Areas

Links

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OverviewAI-generated summary

Kevin A. Murach's research focuses on the molecular and cellular mechanisms underlying skeletal muscle adaptation and aging. His work investigates how exercise impacts muscle metabolism and epigenetics, particularly in the context of age-related decline. Murach has published extensively on the role of satellite cells in muscle growth and repair, and on how interventions like senolytic treatments can mitigate age-related deficits in muscle regeneration and hypertrophy.

His federally funded research includes two NIH/National Institute on Aging grants totaling $384,676, focused on the myonuclear epigenetics of skeletal muscle mass regulation with age and the mediators of muscle rejuvenation. These grants support his study of how epigenetic modifications in muscle nuclei contribute to changes in muscle mass over an individual's lifespan. Murach also leads a research group at the University of Arkansas at Fayetteville and collaborates with several faculty members within the institution, including Nicholas P. Greene, Francielly Morena da Silva, Pieter J Koopmans, and Sabin Khadgi, with whom he has co-authored multiple publications.

With a publication record of 145 articles and an h-index of 35, Murach is recognized as a highly cited researcher. His work has garnered significant attention within the scientific community for its contributions to understanding muscle physiology, aging, and the potential for exercise and therapeutic interventions to enhance muscle health.

Metrics

h-index: 35
Publications: 145
Citations: 3,569

Selected Publications

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle (2025) DOI
Power and Endurance: Polar Opposites or Willing Partners? (2025) DOI
microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism (2025) DOI
Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025) DOI
At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( <scp>BI01</scp> ) Administration on <scp>DNA</scp> Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle (2025) DOI
A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review (2025) DOI
A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity (2025) DOI
A primer on global molecular responses to exercise in skeletal muscle: Omics in focus (2025) DOI
Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024) DOI
Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024) DOI
Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci (2024) DOI
microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism (2024) DOI
Skeletal muscle hypertrophy: cell growth is cell growth (2024) DOI
Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health (2024) DOI
Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia (2024) DOI