Roy Morello Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

Federal Grant PI High Impact

Professor

University of Arkansas for Medical Sciences

faculty

30 h-index 80 pubs 3,947 cited

Research Areas

Links

ORCID Lab Website UAMS TRI Profile

Edit your profile

OverviewAI-generated summary

Roy Morello's research investigates the genetic and molecular underpinnings of skeletal and lung development, with a particular focus on connective tissue disorders. He has published on topics including the NAD salvage pathway's role in skeletal development, the osteocyte transcriptome, and alterations in type I collagen that lead to defects in bone and lung function. Morello's work has utilized mouse models to study conditions such as osteogenesis imperfecta and classical Ehlers-Danlos syndrome, examining how specific gene mutations, like those in COL5A1 and COL1A1, result in intrinsic respiratory and lung defects.

His work also extends to exploring potential therapeutic targets, including small molecule agonists for the Relaxin Family Peptide Receptor 2. Morello is a principal investigator on federal grants, including an NIH/National Heart Lung and Blood Institute award of $380,648 for his study on lung developmental defects caused by type I collagen mutations in mouse models of osteogenesis imperfecta. His scholarship metrics indicate a significant publication record, with an h-index of 30 and over 3,900 citations across 80 publications. Morello collaborates with researchers at the University of Arkansas for Medical Sciences, including Milena Dimori, Charles A. O’Brien, Jeff D. Thostenson, and John T. Sherrill.

Metrics

h-index: 30
Publications: 80
Citations: 3,947

Selected Publications

Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice (2025) DOI
A new <i>Col1a1</i> conditional knock-in mouse model to study osteogenesis imperfecta (2024) DOI
A New Mouse Model to Dissect the Contribution of Intrinsic Lung Defects Versus Extrinsic Skeletal Defects to Impaired Lung Function in Osteogenesis Imperfecta (2024) DOI
The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice (2023) DOI
A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation (2023) DOI
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2 (2022) DOI
Distinct type I collagen alterations cause intrinsic lung and respiratory defects of variable severity in mouse models of osteogenesis imperfecta (2022) DOI
RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis (2022) DOI
Haploinsufficiency of <i>Col5a1</i> causes intrinsic lung and respiratory changes in a mouse model of classical Ehlers‐Danlos syndrome (2022) DOI
The Osteocyte Transcriptome: Discovering Messages Buried Within Bone (2021) DOI