Nisreen Akel

Researcher

University of Arkansas for Medical Sciences

faculty

19 h-index 41 pubs 2,012 cited

Research Areas

Bone Metabolism and Diseases Diabetes Management and Research Pharmacological Effects and Toxicity Studies Metabolism and Genetic Disorders Bone health and osteoporosis research Molecular Biology Techniques and Applications Orthopedic Surgery and Rehabilitation

Links

ORCID Lab Website

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OverviewAI-generated summary

Nisreen Akel's research focuses on understanding and treating bone disorders, particularly those associated with diabetes and glucocorticoid use. Her work has investigated the role of specific cellular pathways, such as chaperone-mediated autophagy, in bone mass regulation and age-related bone loss. Akel has explored therapeutic strategies, including the use of sclerostin antibodies to correct periodontal disease in diabetic mice and the development of bone-targeted inhibitors like BT-Amide for preventing glucocorticoid-induced bone loss. Her publications also include work on the effectiveness of anabolic therapies in reversing diabetic bone signatures. Akel collaborates with researchers at the University of Arkansas for Medical Sciences, including Teresita Bellido, Amy Y. Sato, Gaston Troncoso, and Betiana Perez. She has an h-index of 19, with over 2,000 citations across 41 publications.

Metrics

  • h-index: 19
  • Publications: 41
  • Citations: 2,012

Selected Publications

  • Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss (2024) DOI
  • Sclerostin antibody corrects periodontal disease in type 2 diabetic mice (2024) DOI
  • Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice (2024) DOI
  • THU346 Repairing Skeletal Deterioration In Diabetes With Bone Anabolic Therapies (2023) DOI
  • CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system (2023) DOI
  • Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice (2023) DOI
  • Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice (2023) DOI
  • Reversal of the diabetic bone signature with anabolic therapies in mice (2023) DOI
  • Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass (2022) DOI

Collaborators

Researchers in the database who share publications

Teresita Bellido University of Arkansas for Medical Sciences 6 shared publications Amy Y. Sato University of Arkansas for Medical Sciences 5 shared publications Gaston Troncoso University of Arkansas for Medical Sciences 4 shared publications Betiana Perez University of Arkansas for Medical Sciences 4 shared publications Jomeeka Meeks University of Arkansas for Medical Sciences 4 shared publications Intawat Nookaew University of Arkansas for Medical Sciences 3 shared publications Melda Onal University of Arkansas for Medical Sciences 3 shared publications Dominique J. Laster University of Arkansas for Medical Sciences 3 shared publications

Similar Researchers

Based on overlapping research topics

Betiana Perez University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Diabetes Management and Research Metabolism and Genetic Disorders
Good match 3 shared topics
Jomeeka Meeks University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Diabetes Management and Research Metabolism and Genetic Disorders
Good match 3 shared topics
Stavros C. Manolagas University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Metabolism and Genetic Disorders Molecular Biology Techniques and Applications
Good match 4 shared topics
Melvin Dassinger Iii University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Metabolism and Genetic Disorders Molecular Biology Techniques and Applications
Good match 3 shared topics
Joseph J. Goellner University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Pharmacological Effects and Toxicity Studies Orthopedic Surgery and Rehabilitation
Good match 3 shared topics
Teenamol E. Joseph University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Metabolism and Genetic Disorders Molecular Biology Techniques and Applications
Good match 3 shared topics