David R. Proffitt

Researcher

University of Arkansas for Medical Sciences

grad_student

1 h-index 2 pubs 8 cited

Research Areas

Molecular Biology Techniques and Applications Protein Structure and Dynamics Mitochondrial Function and Pathology Genomics and Phylogenetic Studies DNA Repair Mechanisms

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OverviewAI-generated summary

David R. Proffitt's research focuses on molecular biology, specifically investigating the functions of the Pif1 helicase. His work has explored how Pif1 helicase remodels protein-nucleic acid complexes and its role in both nuclear and mitochondrial functions. Proffitt has identified specific residues in the DNA binding site of Pif1 that are crucial for its nuclear activities, while being dispensable for mitochondrial respiratory growth. His recent publications in 2023 and 2024 highlight these investigations. Proffitt collaborates with researchers at the University of Arkansas for Medical Sciences, including John C. Marecki, Wayne P. Wahls, and Reine U. Protacio, with whom he has co-authored publications.

Metrics

  • h-index: 1
  • Publications: 2
  • Citations: 8

Selected Publications

  • Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024) DOI
  • Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA (2023) DOI

Collaborators

Researchers in the database who share publications

John C. Marecki University of Arkansas for Medical Sciences 1 shared publication Wayne P. Wahls University of Arkansas for Medical Sciences 1 shared publication Reine U. Protacio University of Arkansas for Medical Sciences 1 shared publication

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