Wayne P. Wahls
Professor
University of Arkansas for Medical Sciences
faculty
Biochemistry & Molecular Biology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Wayne P. Wahls, Professor in the Department of Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences, conducts research focused on understanding the molecular mechanisms that govern DNA repair, recombination, and genome editing. His work investigates how environmental factors and evolutionary processes influence these fundamental biological processes, with a particular interest in meiotic recombination. Wahls has received federal funding for his research, including a $423,218 grant from the NIH/National Institute of General Medical Sciences to systematically elucidate DNA sequence codes regulating meiotic recombination.
His recent publications explore various aspects of molecular biology, including the function of eukaryotic Pif1 helicase in unwinding DNA structures and its role in nuclear and mitochondrial functions. Wahls' lab also investigates the efficiency and outcomes of CRISPR/Cas9-mediated genome editing in yeast, highlighting how distance-dependent effects can compromise accuracy and lead to unintended genetic alterations. The group's research also extends to practical laboratory challenges, such as issues with agar composition affecting yeast cell growth and plating efficiency.
With 74 total publications and an h-index of 25, Wahls is recognized as a highly cited researcher. He actively collaborates with colleagues at the University of Arkansas for Medical Sciences, including Reine U. Protacio and Emory G. Malone, as well as researchers at the University of Arkansas at Fayetteville, such as Jeffrey A. Lewis and Stephanie E. Hood.
Metrics
- h-index: 25
- Publications: 74
- Citations: 2,187
Selected Publications
- Dynamic global acetylation remodeling during the yeast heat shock response (2026) DOI
- Dynamic global acetylation remodeling during the yeast heat shock response (2026) DOI
- Dynamic global acetylation remodeling during the yeast heat shock response (2025) DOI
- Agar lot-specific inhibition in the plating efficiency of yeast spores and cells (2024) DOI
- Creating Meiotic Recombination-Regulating DNA Sites by SpEDIT in Fission Yeast Reveals Inefficiencies, Target-Site Duplications, and Ectopic Insertions (2024) DOI
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024) DOI
- Laboratory horror stories: Poison in the agars (2024) DOI
- Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024) DOI
- Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution (2022) DOI
- Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination (2021) DOI
Federal Grants 1 $423,218 total
Systematic elucidation of DNA sequence codes that regulate meiotic recombination
Grants & Funding
- No FP attached UAMS College of Medicine Principal Investigator
- Combinatoial CREB/ATF dimers and cellular growth control NIH Principal Investigator
- Transcription-coupled Homologous Recombination Human Frontier Science Program Principal Investigator
- Systematic elucidation of DNA sequence codes that regulate meiotic recombination NIH Principal Investigator
- Systematic elucidation of DNA sequence codes that regulate meiotic recombination NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
- Transcription-coupled Homologous Recombination Human Frontier Science Program Principal Investigator
- Biochemistry of recombination in meiosis NIH Principal Investigator
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