Gwen V. Childs

Federal Grant PI High Impact

Distinguished Professor

University of Arkansas for Medical Sciences

faculty

childsgwenv@uams.edu

50 h-index 285 pubs 7,803 cited

Research Areas

Molecular Biology Techniques and Applications Receptor Mechanisms and Signaling RNA and protein synthesis mechanisms Diet and metabolism studies Adipose Tissue and Metabolism Neuroscience and Neuropharmacology Research Health and Medical Research Impacts

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Gwen V. Childs is a Distinguished Professor at the University of Arkansas for Medical Sciences. Her research focuses on the molecular mechanisms of pituitary plasticity, particularly how regulated mRNA translation controls pituitary cell function. She has received federal funding from the National Institutes of Health (NIH) for her work in this area. Current projects include investigating the impact of obesity on somatotrope function and exploring the molecular mechanisms underlying pituitary plasticity. Her scholarly output includes over 285 publications and her work has been cited more than 7,800 times, with an h-index of 50.

Childs' recent publications investigate the regulatory landscape of the murine pituitary through single nucleus multi-omics, the role of adipo-glial signaling in peripheral nerve regeneration, and the impact of high-fat diets on anterior pituitary transcriptomics and cell metabolism. Further research explores how Musashi RNA-binding proteins control gonadotrope target mRNA translation during the mouse estrous cycle and mediate translational activation through interactions with the LSM14B protein. Additionally, her work examines how leptin receptor signaling ablation alters somatotrope transcriptome maturation in female mice.

Metrics

  • h-index: 50
  • Publications: 285
  • Citations: 7,803

Selected Publications

  • OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025) DOI
  • SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025) DOI
  • SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025) DOI
  • High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025) DOI
  • Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B (2025) DOI
  • Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025) DOI
  • Solving the Mystery of the Neonatal GH Surge (2024) DOI
  • 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024) DOI
  • 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024) DOI
  • The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024) DOI
  • Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024) DOI
  • Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023) DOI
  • Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration (2023) DOI
  • FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023) DOI
  • OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes (2023) DOI

Federal Grants 3 $1,788,568 total

NIH/National Institute of Diabetes and Digestive and Kidney Diseases Co-PI Sep 2024 - May 2029

Molecular mechanisms of pituitary plasticity

National Institute of Diabetes and Digestive and Kidney Diseases $637,340 R01
NIH/National Institute of Diabetes and Digestive and Kidney Diseases Contact PI Jul 2021 - Jun 2026

The Impact of Obesity on Somatotrope Function

National Institute of Diabetes and Digestive and Kidney Diseases $549,786 R01
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development Co-PI Sep 2018 - Jun 2025

Control of pituitary cell plasticity through regulated mRNA translation

Eunice Kennedy Shriver National Institute of Child Health and Human Development $601,442 R01

Grants & Funding

Collaborators

Researchers in the database who share publications

Angus M. MacNicol University of Arkansas for Medical Sciences 27 shared publications Melanie Clair Macnicol University of Arkansas for Medical Sciences 25 shared publications Angela K. Odle University of Arkansas for Medical Sciences 24 shared publications Anessa Haney University of Arkansas for Medical Sciences 15 shared publications Tiffany K. Miles University of Arkansas for Medical Sciences 14 shared publications Alex Lagasse University of Arkansas for Medical Sciences 13 shared publications Jewel Banik University of Arkansas for Medical Sciences 11 shared publications Linda Hardy University of Arkansas for Medical Sciences 9 shared publications

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