Tiffany K. Miles

Researcher

University of Arkansas for Medical Sciences

faculty

7 h-index 30 pubs 446 cited

Research Areas

Diet and metabolism studies Receptor Mechanisms and Signaling Metabolism and Genetic Disorders Birth, Development, and Health Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Health and Medical Research Impacts

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OverviewAI-generated summary

Tiffany K. Miles' research investigates the complex interplay of diet, metabolism, and endocrine signaling within the pituitary gland, particularly focusing on the effects of high-fat diets and oxidative stress on cellular function and gene expression. Her work has explored how hormonal signals, such as leptin, influence the differentiation and transcriptome maturation of specific pituitary cell types, including gonadotropes and somatotropes. Miles has also examined the impact of maternal nutritional status, such as caloric restriction, on the pituitary proteome of offspring, with implications for metabolic health later in life. Her research contributes to understanding pituitary plasticity, reproductive cycle regulation, and the molecular mechanisms underlying diet-induced metabolic changes.

Metrics

  • h-index: 7
  • Publications: 30
  • Citations: 446

Selected Publications

  • SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025) DOI
  • High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025) DOI
  • Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025) DOI
  • 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024) DOI
  • 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024) DOI
  • Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024) DOI
  • Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023) DOI
  • FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023) DOI
  • THU043 Single-cell Transcriptomics Show Sex-specific Responses To A High Fat Diet, Under Thermoneutral Conditions, Pointing To Reduced Pituitary Plasticity (2023) DOI
  • Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle (2023) DOI
  • OR23-2 Mild Maternal Undernutrition Results in Transcript Regulation in the Fat of Male Offspring that Correlates with Resistance to High Fat Diet Induced Weight Gain (2022) DOI
  • 410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet (2022) DOI
  • Leptin: A Metabolic Signal for the Differentiation of Pituitary Cells (2021) DOI
  • Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet (2021) DOI

Collaborators

Researchers in the database who share publications

Gwen V. Childs University of Arkansas for Medical Sciences 14 shared publications Angela K. Odle University of Arkansas for Medical Sciences 14 shared publications Angus M. MacNicol University of Arkansas for Medical Sciences 13 shared publications Melanie Clair Macnicol University of Arkansas for Medical Sciences 11 shared publications Anessa Haney University of Arkansas for Medical Sciences 10 shared publications Alex Lagasse University of Arkansas for Medical Sciences 10 shared publications Ashley Herdman University of Arkansas for Medical Sciences 6 shared publications Allen Gies University of Arkansas for Medical Sciences 3 shared publications

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