En Huang

Federal Grant PI

Associate Professor

University of Arkansas for Medical Sciences

faculty

Environmental Health Sciences, College of Public Health

18 h-index 48 pubs 909 cited

Research Areas

Bacterial Genetics and Biotechnology Antibiotic Resistance in Bacteria Microbial infections and disease research Food composition and properties Genomics and Phylogenetic Studies Antimicrobial Resistance in Staphylococcus Essential Oils and Antimicrobial Activity Listeria monocytogenes in Food Safety

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

En Huang's research focuses on developing natural antimicrobial compounds to improve food safety and quality. This work includes the discovery and characterization of natural antimicrobial peptides, such as bacteriocins and lipopeptides, utilizing chemical and genetic methodologies. These agents are being investigated for their potential use as natural food preservatives, animal feed additives, or as novel antibiotics to combat drug-resistant bacterial pathogens.

Additional research interests involve studying the transmission, ecology, and evolution of foodborne pathogens and spoilage microorganisms. Huang employs genomic, transcriptomic, and metagenomic approaches for these investigations. Their federal grant funding includes $1 from the NIH/National Institute of Allergy and Infectious Diseases for research into the mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens. Huang has published 48 total publications with 909 total citations and an h-index of 18. They collaborate with several researchers at the University of Arkansas for Medical Sciences, including Se-Ran Jun, Kaleb Z. Abram, Visanu Wanchai, and Intawat Nookaew.

Metrics

  • h-index: 18
  • Publications: 48
  • Citations: 909

Selected Publications

  • Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce (2024) DOI
  • A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts (2024) DOI
  • Thermal Inactivation of Escherichia Phage OSYSP and Host Strain Escherichia coli O157:H7 EDL933: A Comparative Kinetic Analysis (2024) DOI
  • Lytic Escherichia phage OSYSP acts additively and synergistically with gaseous ozone against Escherichia coli O157:H7 on spinach leaves (2023) DOI
  • Carbapenem resistance in the food supply chain (2023) DOI
  • Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas (2022) DOI
  • Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences (2022) DOI
  • Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection (2021) DOI
  • Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States (2021) DOI
  • Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable (2021) DOI
  • Applications in food technology: antimicrobial peptides (2021) DOI

Federal Grants 1 $1 total

NIH/National Institute of Allergy and Infectious Diseases Contact PI Sep 2024 - Sep 2025

Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens

National Institute of Allergy and Infectious Diseases $1 R01

Grants & Funding

  • Novel linear lipopeptide paenipeptins sensitize multidrug-resistant Gram-negative pathogens to antibiotics - Continuation Year 2020-2021 NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Real-Time High Resolution Method for Genomic Surveillance of ESKAPE pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator

Collaborators

Researchers in the database who share publications

Se-Ran Jun University of Arkansas for Medical Sciences 3 shared publications Kaleb Z. Abram University of Arkansas for Medical Sciences 2 shared publications Visanu Wanchai University of Arkansas for Medical Sciences 1 shared publication Intawat Nookaew University of Arkansas for Medical Sciences 1 shared publication Gunnar Boysen University of Arkansas for Medical Sciences 1 shared publication Taylor D. Wadley University of Arkansas for Medical Sciences 1 shared publication Yihong Kaufmann University of Arkansas for Medical Sciences 1 shared publication

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