Heba Allam Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

Assistant Professor

University of Arkansas for Medical Sciences

faculty

7 h-index 26 pubs 307 cited

Research Areas

DNA Repair Mechanisms Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Immune Cell Function and Interaction Microbial infections and disease research

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Heba Allam's research focuses on molecular mechanisms underlying cellular responses to genotoxic stress and therapeutic interventions. Her work has investigated the role of Glycogen Synthase Kinase-3β (GSK3B) in DNA repair pathways, specifically its influence on the choice between different repair mechanisms and its impact on tumor response to PARP1 inhibitors. Allam has also explored the function of SIRT2 in maintaining oral stem cell resilience, particularly in the context of radiation mucositis, and its role in promoting homologous recombination-mediated DNA double-strand break repair. Her publications include studies on inhibiting GSK3B phosphorylation to enhance T cell infiltration and cytotoxicity against head and neck squamous cell carcinoma, as well as in silico identification of drug targets for Erwinia amylovora to control fire blight. Allam's scholarship metrics include an h-index of 7 with 26 total publications and 307 citations. She collaborates with researchers at the University of Arkansas for Medical Sciences, including Mousumi Patra and Ratan Sadhukhan.

Metrics

  • h-index: 7
  • Publications: 26
  • Citations: 307

Selected Publications

  • GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1 (2025) DOI
  • Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells (2025) DOI
  • 376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma (2024) DOI
  • Abstract PR011: Novel role of glycogen synthase kinase-3β in determining cancer cell response to PARPi through regulation of 53BP1 function (2024) DOI
  • Novel Role of Glycogen Synthase Kinase-3β in Determining Cancer Cell Response to Genotoxic Stress through Regulation of 53BP1 Function (2023) DOI

Grants & Funding

Collaborators

Researchers in the database who share publications

Mousumi Patra University of Arkansas for Medical Sciences 6 shared publications Ratan Sadhukhan University of Arkansas for Medical Sciences 4 shared publications Brian Koss University of Arkansas for Medical Sciences 1 shared publication Yong‐Chen Lu University of Arkansas for Medical Sciences 1 shared publication Kirk L. West University of Arkansas for Medical Sciences 1 shared publication Forouh Kalantari University of Arkansas for Medical Sciences 1 shared publication F. Kalantari University of Arkansas for Medical Sciences 1 shared publication

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