Jeanne Y. Wei

High Impact

Department Chairperson

University of Arkansas for Medical Sciences

faculty

Department Chairs, College of Medicine

56 h-index 666 pubs 14,135 cited

Research Areas

Nutrition and Health in Aging Mitochondrial Function and Pathology Cardiovascular Function and Risk Factors Geriatric Care and Nursing Homes Epigenetics and DNA Methylation Pharmacological Effects and Toxicity Studies Diet and metabolism studies

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Jeanne Y. Wei, M.D., Ph.D., holds the Jackson T. Stephens Professorship of Geriatrics in the College of Medicine at the University of Arkansas for Medical Sciences (UAMS). She also serves as Chair of the Reynolds Department of Geriatrics and Executive Director of the Reynolds Institute on Aging (RIOA). Dr. Wei's clinical expertise includes board certification in internal medicine, geriatrics, and cardiovascular medicine. She sees patients at the Thomas and Lyon Longevity Clinic within RIOA.

Dr. Wei's research interests primarily focus on the aging cardiovascular system. She has maintained continuous NIH funding for over 30 years. Her scholarly work has resulted in a substantial publication record, with a h-index of 56, over 666 publications, and more than 14,000 citations. She has contributed to studies examining mitochondrial function, oxidative stress, and the effects of specific dietary supplements and compounds on physical performance and cellular processes in older adults. Her research has also explored DNA methylation signatures related to cardiotoxicity and the modulation of mitochondrial functions by specific inhibitors.

Prior to joining UAMS, Dr. Wei held faculty positions at Harvard Medical School and Beth Israel Hospital in Boston, where she directed the Division on Aging and served as chief of the Gerontology Division at Beth Israel Deaconess Medical Center. She has also contributed to scientific review processes, serving on NIH peer review study sections and chairing the NIA Board of Scientific Counselors.

Research Overview

Jeanne Y. Wei, M.D., Ph.D., Jackson T. Stephens Professor of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences (UAMS), is Chair, Reynolds Department of Geriatrics & Executive Director of the Reynolds Institute on Aging (RIOA). Dr. Wei is board certified in internal medicine, geriatrics & cardiovascular medicine and sees patients in the Thomas and Lyon Longevity Clinic at RIOA. After obtaining M.D. and Ph.D. degrees from the University of Illinois, Dr. Wei completed an internal medicine residency and cardiology fellowship at the Johns Hopkins Hospital as well as a staff fellowship in Gerontology at NIH/NIA in Baltimore, MD. She then joined the faculty at Harvard Medical School and Beth Israel Hospital in Boston, and became director of the Division on Aging at Harvard and chief of the Gerontology Division Beth Israel Deaconess Medical Center. In 2002, she joined the faculty at UAMS. She has received continuous NIH funding for more than 30 years. Her major research interests include the aging cardiovascular system. Dr. Wei has served on NIH peer review study sections, National Institute on Aging (NIA) and was chairman of the NIA Board of Scientific Counselors. In addition, she has served on advisory boards of research foundations, pharmaceutical companies and the FDA. She has published more than 200 scientific articles, served on multiple editorial boards and is a reviewer of 34 peer-review scientific journals. She has authored six books, including one geriatrics textbook, and AGING WELL: The Complete Guide to Physical and Emotional Health, a health guide for the general public. Jeanne has more than 35 years of experience in caring for patients, training future geriatricians and cardiologists, conducting geriatric and gerontological research, mentoring geriatric fellows and junior faculty members, and developing academic programs and initiatives. A gifted teacher, Dr. Wei received the 'Outstanding Clinical Educator Award' from Harvard Medical School in 2000 and the 'Outstanding Woman Faculty Award' from the UAMS College of Medicine in 2005. She is recognized nationally and internationally for her contributions to aging research.

Metrics

h-index: 56
Publications: 666
Citations: 14,135

Selected Publications

Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief (2025) DOI
Mitochondrial Dynamics in Aging Heart (2025) DOI
Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases (2025) DOI
Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025) DOI
Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025) DOI
DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024) DOI
P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024) DOI
The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment (2024) DOI
Missed Insights for Earlier Management of Parkinson’s Disease and the Value of Dopamine Transporter (DAT) Scans (2024) DOI
Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer (2024) DOI
The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024) DOI
RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity (2024) DOI
Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024) DOI
Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function (2024) DOI
Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024) DOI

Grants & Funding

Transcription Regulation in the Aging Heart NIH Principal Investigator
PRagmatic EValuation of evENTS And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) (IRB 274254) NIH/Nat. Inst. on Aging - Pass Through: Duke University Principal Investigator
Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) (IRB 274855) NIH/Nat. Inst. on Aging - Pass Through: Johns Hopkins University Principal Investigator
Predicting CHD Events in Black and White Women NIH Co-Investigator
Subcontract w/Essential Blends, LLC: UpBeat Phase 2 NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC Co-Investigator
GLORIA-AF; Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patient Boehringer Ingleheim Pharmaceuticals, Inc. Principal Investigator
DAABHS SOR III OPAL Narcan Drug Project Substance Abuse & Mental Health Services Administration - Pass Through: Arkansas Department of Human Services Principal Investigator
Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC Co-Investigator