Yunmeng Liu
Assistant Professor
University of Arkansas for Medical Sciences
faculty
Pharmacology & Toxicology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Yunmeng Liu's research focuses on investigating the immune system's role in the development and progression of cardiovascular diseases, particularly hypertension and its connections to type 2 diabetes. Liu's work examines how immune cells, such as T cells and macrophages, contribute to conditions like salt-sensitive hypertension and chronic fibrosis in the heart. Recent publications explore the mechanisms by which kidney-resident memory CD8+ T cells anchor hypertension and how cytokines drive macrophage transitions that promote cardiac fibrosis and diastolic dysfunction. The research also delves into immune dysregulation linking type 2 diabetes with cardiovascular complications, highlighting potential therapeutic targets. Liu has a h-index of 4 with 15 publications and 146 citations. Key collaborators include Katherine Deck, Christoph Mora, Shengyu Mu, and Tonya Rafferty, all from the University of Arkansas for Medical Sciences, with whom Liu has co-authored multiple publications.
Metrics
- h-index: 4
- Publications: 15
- Citations: 146
Selected Publications
- IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287 (2025) DOI
- Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288 (2025) DOI
- Uncovering immune pathways for therapeutic targeting of hypertension (2025) DOI
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025) DOI
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025) DOI
- Establishment of resident memory T cells anchors hypertension in the kidney (2025) DOI
- Abstract MP36: Excessive ATP Promotes Hypertension Via Stimulating T cells (2024) DOI
- O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION (2024) DOI
- Immune Disorders Connecting Type2 Diabetes and Cardiovascular Complications (2024) DOI
Research Interests
Metabolic syndrome persists as a leading cause of morbidity and mortality among adults in the United States. Specifically, the co-existence of diabetes and hypertension, hallmark components of metabolic syndrome, stand as primary contributors to cardiovascular disease and subsequent mortality. Thus, it is important to identify the pathogenic connection between diabetes and hypertension. Ample evidence suggested the involvement of immune cells, particularly T cells, in the pathogenesis of diabetes and hypertension. However, the precise mechanisms by which immune dysregulation associated with diabetes contributes to hypertension are not fully understood. Our research centers on investigating new intrinsic cellular mechanisms existing in diabetic conditions, which sustain chronic T cell activation and accentuate the progression of cardiovascular complications.
Grants & Funding
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
- Role of Immune Cells in kidney in the Development of Salt-Sensitive Hypertension American Heart Association (SouthWest Affiliate) Other Key Personnel
- ATP and insulin contribute to chronic inflammation via promoting T-cell activation and memory formation NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- ATP and insulin contribute to chronic inflammation via promoting T-cell activation and memory formation NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- ATP and insulin contribute to chronic inflammation via promoting T-cell activation and memory formation NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- ATP and insulin contribute to chronic inflammation via promoting T-cell activation and memory formation NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- ATP and insulin contribute to chronic inflammation via promoting T-cell activation and memory formation NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- Formation of CD8Trms in the kidney contributes to salt-memory of hypertension American Heart Association Co-Investigator
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