Lokesh Akana

Researcher

University of Arkansas for Medical Sciences

unknown

1 h-index 8 pubs 3 cited

Research Areas

Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Epigenetics and DNA Methylation Diet and metabolism studies Radiation Therapy and Dosimetry Pancreatic and Hepatic Oncology Research Colorectal Cancer Screening and Detection

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OverviewAI-generated summary

Lokesh Akana's research investigates mechanisms to enhance the effectiveness of cancer treatments, particularly radiotherapy, in rectal and pancreatic cancers. His work explores the role of specific molecular targets, such as Cyclin-dependent kinase 1 (CDK1) and SETD2, in modulating cancer cell radiosensitivity. Publications indicate a focus on inhibiting CDK1 to improve outcomes in pancreatic cancer and targeting SETD2 to enhance radiosensitivity and predict response to chemoradiotherapy in rectal cancer. Akana also studies the impact of dietary interventions, such as methionine restriction, on rectal cancer radiosensitivity and gut protection. Further research explores targeting Tri-Methyl-Histone H3 (Lys27) as a novel strategy to improve radiosensitivity and predict treatment response in rectal cancer. His collaborations include work with researchers at the University of Arkansas for Medical Sciences, University of Arkansas at Little Rock, and the University of Central Arkansas.

Metrics

  • h-index: 1
  • Publications: 8
  • Citations: 3

Selected Publications

  • Abstract A033: Targeting SETD2 in Combination with Radiotherapy in Rectal Cancer (2025) DOI
  • Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025) DOI
  • Abstract A011: Enhanced Radiosensitivity of Pancreatic Cancer Achieved through Inhibition of Cyclin-Dependent Kinase 1 (2024) DOI
  • Enhanced radiosensitivity of pancreatic cancer achieved through inhibition of Cyclin-dependent kinase 1 (2024) DOI
  • Abstract A006: Targeting SETD2 in combination with radiotherapy in rectal cancer (2024) DOI
  • Targeting Tri-Methyl-Histone H3 (Lys27) in Rectal Cancer: A Novel Strategy to Enhance Radiosensitivity and Predict Response to Neoadjuvant Therapy (2023) DOI

Collaborators

Researchers in the database who share publications

Henrique Rodrigues University of Arkansas for Medical Sciences 4 shared publications Oscar Zuniga University of Arkansas for Medical Sciences 3 shared publications Óscar Zúñiga University of Arkansas at Little Rock 2 shared publications Stetson Van Matre University of Central Arkansas 2 shared publications Eric U. Yee University of Arkansas for Medical Sciences 1 shared publication Nükhet Aykin‐Burns University of Arkansas for Medical Sciences 1 shared publication Tatiana Wolfe University of Arkansas for Medical Sciences 1 shared publication Isabelle Racine Miousse University of Arkansas for Medical Sciences 1 shared publication

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