Lydia M. Bilinsky Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

unknown

4 h-index 8 pubs 66 cited

Research Areas

Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Carcinogens and Genotoxicity Assessment Bioinformatics and Genomic Networks Computational Drug Discovery Methods

Links

ORCID

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Lydia M. Bilinsky's research focuses on the development and application of computational models to understand biological processes, particularly concerning cellular metabolism and oxidative stress. Her recent work includes a 2024 publication detailing a computational model of endogenous hydrogen peroxide metabolism in hepatocytes, highlighting the role of glutathione (GSH). She has also published on a computational model that predicts intracellular H₂O₂ concentration and cell death during oxidative stress, with applications to PBPK/PD modeling of trivalent arsenical DMA<sup>III</sup>. This research provides insights into the critical role of GSH depletion in apoptosis and the regulation of intracellular H₂O₂ concentration. Bilinsky's investigations extend to the kinetic and thermodynamic regulation of mitochondrial energy metabolism and reactive oxygen species (ROS) production, as explored in her 2022 publication. Her scholarly contributions are reflected in a h-index of 4 across 8 publications, with a total of 66 citations.

Metrics

  • h-index: 4
  • Publications: 8
  • Citations: 66

Selected Publications

  • A computational model of endogenous hydrogen peroxide metabolism in hepatocytes, featuring a critical role for GSH (2024) DOI
  • A Computational Model of Hydrogen Peroxide Production in Liver and its Removal by Catalase and GSH-reliant Enzymes that Can Predict Intracellular H <sub>2</sub> O <sub>2</sub> Concentration and Cell Death During Incidents of Extreme Oxidative Stress: (1) Applications to PBPK/PD Modeling of the Trivalent Arsenical DMA <i> <sup>III</sup> </i> , (2) Insights Obtained into (a) the Role of Critical GSH Depletion in Apoptosis and (b) How Intracellular H <sub>2</sub> O <sub>2</sub> Concentration is So Tightly Regulated (2023) DOI

Similar Researchers

Based on overlapping research topics

D Paine National Center for Toxicological Research
Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment
Good match 3 shared topics
Sasin Payakachat University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment
Good match 3 shared topics
Me-Kyoung Choi National Center for Toxicological Research
Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment
Good match 3 shared topics
Kamel Mansouri National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Bioinformatics and Genomic Networks
Good match 4 shared topics
Kristin Ashby National Center for Toxicological Research
Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Bioinformatics and Genomic Networks
Good match 4 shared topics
Dong-Jin Yang National Center for Toxicological Research
Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment
Good match 3 shared topics