Rajan Thakur Source Confirmed
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
John Brown University
faculty
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Biography and Research Information
OverviewAI-generated summary
Rajan Thakur, a faculty member at John Brown University, investigates the intricate relationship between lipid metabolism and organelle communication in shaping synapse development, function, and remodeling. His research employs Drosophila genetics, CRISPR-based engineering, advanced microscopy, electrophysiology, and biochemical assays to dissect lipid-driven mechanisms underlying neuronal communication and dysfunction in the context of both neurodevelopmental and neurodegenerative diseases.
Thakur's work has illuminated the role of ER-lysosome contacts and lipid transfer proteins in defining synaptic architecture and activity. Recent studies have uncovered how PDZD8 promotes autophagy at ER-lysosome contact sites to regulate synaptogenesis and activity-dependent synaptic growth. He has also explored the function of tRNA methyltransferases in synaptic growth and the roles of bulk lipid transporters VPS13A and BLTP2 in neurodegenerative and neurodevelopmental processes. Further, he values collaborative science, mentorship, and inclusive teaching.
Metrics
- h-index: 7
- Publications: 22
- Citations: 267
Selected Publications
- PDZD8 links organelle crosstalk to synaptic remodeling via autophagy (2025) DOI
- Neurodegenerative and neurodevelopmental roles for bulk lipid transporters <i>VPS13A</i> and <i>BLTP2</i> in movement disorders (2024) DOI
- Author Reply to Peer Reviews of A genetic and physiological model of renal dysfunction in Lowe syndrome (2024) DOI
- Analysis of Lipid Signaling in <em>Drosophila</em> Photoreceptors using Mass Spectrometry (2022) DOI
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