William Slikker Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Director

National Center for Toxicological Research

faculty

67 h-index 480 pubs 19,516 cited

Research Areas

Neuroscience and Neuropharmacology Research Pharmacological Effects and Toxicity Studies Health and Medical Research Impacts Nanoparticles: synthesis and applications Artificial Intelligence and Machine Learning Applications Medical Imaging Techniques and Applications Bioinformatics and Genomic Networks Anesthesia and Neurotoxicity Research

Links

ORCID Lab Website

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OverviewAI-generated summary

William Slikker directs research focused on regulatory science, with a particular emphasis on toxicology and the application of emerging technologies. His work has explored the regulatory landscape of nanotechnology and nanoplastics from a global perspective, and the impact of new technologies on regulatory science frameworks. He has also investigated the intersection of artificial intelligence, real-world data, and public health, specifically in the context of drug and food safety.

Slikker's research extends to neuroprotection and neurotoxicity. He has studied the neurochemical effects of long-term methylphenidate treatment in nonhuman primates using microPET/CT imaging. His laboratory has also focused on establishing neural stem cells from fetal monkey brains for neurotoxicity testing and has investigated the neuroprotective potential of carnitine. His work also includes the transition from traditional animal models to New Approach Methodologies (NAMs) to protect human and animal health.

With an h-index of 67 and over 480 publications, Slikker is recognized as a highly cited researcher. His key collaborators include Tucker A. Patterson, Leah E. Latham, John Talpos, and Weida Tong, all from the National Center for Toxicological Research. He maintains an active laboratory website to disseminate his research.

Metrics

  • h-index: 67
  • Publications: 480
  • Citations: 19,516

Selected Publications

  • Proposed key characteristics of neurotoxic chemicals (2025) DOI
  • Biomarkers of Neurotoxicity and Disease (2025) DOI
  • Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods (2024) DOI
  • Integrating artificial intelligence with bioinformatics promotes public health (2023) DOI
  • In pursuit of precision medicine for brain injury and neurotoxicity and improved protection of human health (2023) DOI
  • Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action (2023) DOI
  • Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023) DOI
  • Artificial intelligence and real-world data for drug and food safety – A regulatory science perspective (2023) DOI
  • Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023) DOI
  • Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity (2022) DOI
  • Phencyclidine (PCP)-induced neurotoxicity and behavioral deficits (2022) DOI
  • Analysis of biofluid lipid changes: potential biomarkers for detecting central nervous system diseases and neurotoxicity (2021) DOI
  • MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021) DOI
  • Regulatory landscape of nanotechnology and nanoplastics from a global perspective (2021) DOI
  • Neuroprotective Effects of Carnitine and Its Potential Application to Ameliorate Neurotoxicity (2021) DOI

Collaborators

Researchers in the database who share publications

Tucker A. Patterson National Center for Toxicological Research 7 shared publications Leah E. Latham National Center for Toxicological Research 4 shared publications John Talpos National Center for Toxicological Research 4 shared publications Weida Tong National Center for Toxicological Research 4 shared publications Shuliang Liu National Center for Toxicological Research 3 shared publications Serguei Liachenko National Center for Toxicological Research 3 shared publications Merle G. Paule National Center for Toxicological Research 3 shared publications Anil K. Patri National Center for Toxicological Research 2 shared publications

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