Ratan Sadhukhan

Post Doctoral Fellow

University of Arkansas for Medical Sciences

postdoc

Radiation Oncology, College of Medicine

11 h-index 30 pubs 453 cited

Research Areas

DNA Repair Mechanisms Cancer-related molecular mechanisms research Radiation Therapy and Dosimetry Immune Cell Function and Interaction Diet and metabolism studies Neuroscience and Neuropharmacology Research Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies

Links

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OverviewAI-generated summary

Ratan Sadhukhan's research focuses on molecular mechanisms underlying cellular responses to damage and therapeutic interventions, particularly in the context of cancer and radiation therapy. His work investigates the roles of specific proteins and signaling pathways, such as PARP1 and SIRT2, in DNA repair, genetic stability, and the mitigation of treatment-induced side effects like oral mucositis. Sadhukhan has explored how dietary factors and specific compounds, like nicotinamide riboside, can influence cellular resilience and alleviate treatment toxicity.

His publications include studies on the impact of methionine deficiency on genetic instability, the neuroprotective effects of nicotinamide riboside against cisplatin-induced neuropathy, and the function of PARP1 in telomere maintenance. He has also investigated the involvement of EZH2 and SOX2 in lung cancer and the role of GSK3B in DNA repair choice and response to PARP1 inhibition. Sadhukhan's scholarship metrics include an h-index of 11 with 30 publications and 453 citations. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Mousumi Patra and Heba Allam.

Metrics

  • h-index: 11
  • Publications: 30
  • Citations: 453

Selected Publications

  • SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells (2026) DOI
  • GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1 (2025) DOI
  • Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells (2025) DOI
  • Screening and identification of gene expression in large cohorts of clinical tissue samples unveils the major involvement of EZH2 and SOX2 in lung cancer (2024) DOI
  • 376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma (2024) DOI
  • Screening and Identification of Gene Expression in Large Cohorts of Clinical Tissue Samples Unveils the Major Involvement of Ezh2 and Sox2 in Lung Cancer (2024) DOI
  • Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2 (2024) DOI
  • Nicotinamide Riboside Alleviates Cisplatin-Induced Peripheral Neuropathy via SIRT2 Activation (2022) DOI
  • Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation (2022) DOI
  • Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells (2021) DOI

Grants & Funding

  • Safeguarding vascular endothelial damage during deep-space missions by newly designed water-soluble vitamin E formulation National Aeronautics & Space Administration - Pass Through: University of Arkansas at Little Rock Principal Investigator
  • Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator

Collaborators

Researchers in the database who share publications

Mousumi Patra University of Arkansas for Medical Sciences 5 shared publications Heba Allam University of Arkansas for Medical Sciences 4 shared publications Brian Koss University of Arkansas for Medical Sciences 1 shared publication Yong‐Chen Lu University of Arkansas for Medical Sciences 1 shared publication Igor Koturbash University of Arkansas for Medical Sciences 1 shared publication Martin Hauer‐Jensen University of Arkansas for Medical Sciences 1 shared publication Regina Lichti Binz University of Arkansas for Medical Sciences 1 shared publication Isabelle Racine Miousse University of Arkansas for Medical Sciences 1 shared publication

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Heba Allam University of Arkansas for Medical Sciences
DNA Repair Mechanisms Cancer-related molecular mechanisms research Immune Cell Function and Interaction
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