Amit Ketkar
Instructor
University of Arkansas for Medical Sciences
faculty
Biochemistry & Molecular Biology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Amit Ketkar's research focuses on mechanisms of DNA damage tolerance and repair, particularly in the context of cancer. His work investigates the roles of specific proteins and cellular processes in maintaining genomic stability and how their disruption can contribute to disease development. Ketkar has published studies on the function of human Rev1 in recognizing and processing DNA structures like G-quadruplex motifs, essential for accurate DNA replication. He also studies the impact of inhibiting enzymes such as tryptophan 2,3-dioxygenase and DNA polymerase kappa on DNA repair pathways in glioma cells. Further investigations have explored how modifications to DNA polymerase kappa can affect the cellular response to replication stress and overall genomic instability in glioblastoma.
Metrics
- h-index: 19
- Publications: 42
- Citations: 823
Selected Publications
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis (2023) DOI
- Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M<sub>1</sub>dG, the Genomic Metabolite of M<sub>1</sub>dG, and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι (2021) DOI
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK (2021) DOI
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021) DOI
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021) DOI
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021) DOI
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021) DOI
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021) DOI
Grants & Funding
- Translesion DNA polymerase kappa activity in gliomas NIH Co-Investigator
- Replication of G-quadruplex DNA by translesion polymerases National Science Foundation Co-Investigator
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