Mitchell R. McGill

Federal Grant PI High Impact

Assistant Professor

University of Arkansas for Medical Sciences

faculty

Environmental Health Sciences, College of Public Health

45 h-index 148 pubs 9,510 cited

Research Areas

Drug-Induced Hepatotoxicity and Protection Metabolism and Genetic Disorders Liver Disease Diagnosis and Treatment Immune Response and Inflammation Mitochondrial Function and Pathology Molecular Biology Techniques and Applications Health and Medical Research Impacts

Links

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OverviewAI-generated summary

Mitchell R. McGill's research focuses on understanding the mechanisms of liver injury and regeneration, particularly in the context of acetaminophen overdose. His work investigates the role of specific molecules and metabolic pathways in the progression and resolution of acute liver failure. McGill has published research on the generation of pro- and anti-inflammatory mediators in patients experiencing acetaminophen overdose, as well as the hepatotoxicity associated with herbal dietary supplements. His publications also explore the use of proteomics to identify prognostic biomarkers, such as lactate dehydrogenase, in acetaminophen-induced acute liver failure, and to reveal altered signaling pathways involved in the disease process.

Further investigations by McGill include examining biomarkers of mitotoxicity after acute liver injury, with a specific focus on glutamate dehydrogenase. He has also studied the critical role of hepatic pyruvate and alanine metabolism in maintaining antioxidant capacity and resistance to oxidative stress. His federally funded research, supported by a $328,034 grant from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases, specifically investigates the role of phosphatidic acid in liver regeneration following acetaminophen overdose. McGill collaborates with researchers at the University of Arkansas for Medical Sciences, including Stefanie Kennon‐McGill, Eric U. Yee, Igor Koturbash, and Felicia D. Allard, with whom he has co-authored multiple publications.

Metrics

h-index: 45
Publications: 148
Citations: 9,510

Selected Publications

Special Issue “Mechanistic and Prognostic Biomarkers in Liver Diseases” (2025) DOI
From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure (2025) DOI
Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025) DOI
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury (2025) DOI
NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025) DOI
Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity (2024) DOI
Intracellular signaling mechanisms of acetaminophen-induced cell death (2024) DOI
Translation of acetaminophen hepatotoxicity mechanisms from models to humans (2024) DOI
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans (2024) DOI
Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024) DOI
Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024) DOI
The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans (2023) DOI
The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review (2023) DOI
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023) DOI
Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations (2023) DOI

Federal Grants 1 $328,034 total

NIH/National Institute of Diabetes and Digestive and Kidney Diseases Contact PI Mar 2024 - Feb 2029

The role of phosphatidic acid in liver regeneration after acetaminophen overdose

National Institute of Diabetes and Digestive and Kidney Diseases $328,034 R01

Grants & Funding

In-vitro assessment of the protective effects of selected ingredients against acetaminophen hepatotoxicity Haleon PLC Principal Investigator
The role of phosphatidic acid in liver regeneration after acetaminophen overdose NIH Principal Investigator
The role of phosphatidic acid in liver regeneration after acetaminophen overdose NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator