Katy S Papineau

Researcher

National Center for Toxicological Research

unknown

2 h-index 5 pubs 36 cited

Research Areas

Drug-Induced Hepatotoxicity and Protection Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Cardiovascular Function and Risk Factors Molecular Biology Techniques and Applications Liver Disease Diagnosis and Treatment

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OverviewAI-generated summary

Katy S Papineau's research focuses on understanding the mechanisms of drug-induced toxicity, particularly in the liver. Her work utilizes advanced in vitro models, such as human liver-on-a-chip systems and induced pluripotent stem cell-derived cardiomyocytes, to investigate cellular responses to pharmaceutical compounds. Papineau has published on the co-culture of human primary hepatocytes and nonparenchymal liver cells for studying drug-induced liver injury and has investigated the cardiotoxicity of oncology drugs using patient-specific iPSC-CMs. Her recent publications also explore the mitochondrial dysfunction caused by pexidartinib in human hepatocytes and the toxicity of tire rubber antiozonants and their byproducts in liver cells. Papineau collaborates with researchers at the National Center for Toxicological Research, including Lijun Ren and Laura K. Schnackenberg, with whom she shares multiple publications.

Metrics

  • h-index: 2
  • Publications: 5
  • Citations: 36

Selected Publications

  • Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025) DOI
  • Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025) DOI
  • Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025) DOI
  • Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024) DOI
  • Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022) DOI

Collaborators

Researchers in the database who share publications

Lijun Ren National Center for Toxicological Research 5 shared publications Laura K. Schnackenberg National Center for Toxicological Research 5 shared publications Tucker A. Patterson National Center for Toxicological Research 2 shared publications Gonçalo Gamboa da Costa National Center for Toxicological Research 2 shared publications William B. Mattes National Center for Toxicological Research 2 shared publications Li Pang National Center for Toxicological Research 2 shared publications Qiang Shi National Center for Toxicological Research 2 shared publications Daniel J. Yeisley National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Li Pang National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology
Strong match 5 shared topics
Laura K. Schnackenberg National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology
Good match 4 shared topics
Mitchell R. McGill University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection Mitochondrial Function and Pathology Molecular Biology Techniques and Applications
Good match 4 shared topics
Yuet-Kin Leung University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Good match 3 shared topics
Stanley K. Ellis University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Molecular Biology Techniques and Applications
Good match 3 shared topics
Ayesha Arefin National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors
Good match 3 shared topics