Reine U. Protacio

Researcher

University of Arkansas for Medical Sciences

unknown

2 h-index 9 pubs 27 cited

Research Areas

Molecular Biology Techniques and Applications Protein Structure and Dynamics Genomics and Phylogenetic Studies Cancer-related molecular mechanisms research DNA Repair Mechanisms

Links

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OverviewAI-generated summary

Reine U. Protacio's research investigates fundamental aspects of molecular biology, with a recent focus on the Pif1 helicase. Publications from 2024 examine the Pif1 helicase's mechanisms for unwinding DNA structures, including G-quadruplexes and double-stranded DNA, identifying specific amino acid residues critical for its nuclear functions. Other work explores methods for targeted genetic analysis in fission yeast, including the use of SpEDIT technology to create recombination-regulating DNA sites and the assessment of resulting inefficiencies and insertions. Earlier research has explored cell death pathways in primary acute lymphoblastic leukemia cells in response to microtubule depolymerization. Protacio has collaborated with Wayne P. Wahls, John C. Marecki, Emory G. Malone, and David R. Proffitt at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 2
  • Publications: 9
  • Citations: 27

Selected Publications

  • Targeted Forward Genetics: Saturating Mutational Analyses of Specific Target Loci Within the Genome (2024) DOI
  • Agar lot-specific inhibition in the plating efficiency of yeast spores and cells (2024) DOI
  • Creating Meiotic Recombination-Regulating DNA Sites by SpEDIT in Fission Yeast Reveals Inefficiencies, Target-Site Duplications, and Ectopic Insertions (2024) DOI
  • Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024) DOI
  • Laboratory horror stories: Poison in the agars (2024) DOI
  • Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024) DOI
  • Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways (2022) DOI

Collaborators

Researchers in the database who share publications

Wayne P. Wahls University of Arkansas for Medical Sciences 6 shared publications John C. Marecki University of Arkansas for Medical Sciences 2 shared publications Emory G. Malone University of Arkansas for Medical Sciences 2 shared publications David R. Proffitt University of Arkansas for Medical Sciences 1 shared publication Bertha Osei University of Arkansas for Medical Sciences 1 shared publication Seth Dixon University of Arkansas for Medical Sciences 1 shared publication M K Davidson University of Arkansas for Medical Sciences 1 shared publication Randall R Rainwater University of Arkansas for Medical Sciences 1 shared publication

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