Nicole Kleinstreuer Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

53 h-index 284 pubs 13,775 cited

Research Areas

Pharmacological Effects and Toxicity Studies Advanced Neural Network Applications Carcinogens and Genotoxicity Assessment Computational Drug Discovery Methods Health and Medical Research Impacts Meta-analysis and systematic reviews AI in cancer detection

Links

ORCID

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OverviewAI-generated summary

Nicole Kleinstreuer's research focuses on the development and application of new approach methodologies (NAMs) in toxicology, particularly as alternatives to traditional animal testing. Her work investigates how to establish scientific confidence in these novel methods, aiming to facilitate their integration into regulatory toxicology and risk assessment processes. This includes the development of *in silico* models and frameworks for using *in vitro* toxicity data in decision-making.

Her publications have explored large-scale modeling of toxicity endpoints using artificial intelligence and deep learning, emphasizing the impact of data quality on the reliability of these computational models. Kleinstreuer also studies the variability inherent in animal toxicity studies, such as acute oral systemic toxicity in rats. Her research network includes collaborators from the National Center for Toxicological Research, with whom she has co-authored multiple publications. Kleinstreuer is recognized as a highly cited researcher, with a significant publication record and citation count.

Metrics

  • h-index: 53
  • Publications: 284
  • Citations: 13,775

Selected Publications

  • Challenges and opportunities for validation of AI-based new approach methods (2025) DOI
  • The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization (2024) DOI
  • Democratizing cheminformatics: interpretable chemical grouping using an automated KNIME workflow (2024) DOI
  • Unlocking the Potential of Clustering and Classification Approaches: Navigating Supervised and Unsupervised Chemical Similarity (2024) DOI
  • Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants (2024) DOI
  • Differences in the anatomy and physiology of the human and rat respiratory tracts and impact on toxicological assessments (2024) DOI
  • 60 Years of the 3Rs symposium: Lessons learned and the road ahead (2024) DOI
  • Evaluation of in silico model predictions for mammalian acute oral toxicity and regulatory application in pesticide hazard and risk assessment (2024) DOI
  • Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency (2024) DOI
  • Free and open-source QSAR-ready workflow for automated standardization of chemical structures in support of QSAR modeling (2024) DOI
  • Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)* (2024) DOI
  • Examining animal testing for risk assessment: A WC-12 workshop report (2024) DOI
  • Computational application of internationally harmonized defined approaches to skin sensitization: DASS App (2024) DOI
  • Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development (2023) DOI
  • International regulatory uses of acute systemic toxicity data and integration of new approach methodologies (2023) DOI

Collaborators

Researchers in the database who share publications

Kamel Mansouri National Center for Toxicological Research 8 shared publications Weida Tong National Center for Toxicological Research 1 shared publication Frederick A. Beland National Center for Toxicological Research 1 shared publication Luísa Camacho National Center for Toxicological Research 1 shared publication Robert P. Felton National Center for Toxicological Research 1 shared publication Alec T. Salminen National Center for Toxicological Research 1 shared publication Linda S. VonTungeln National Center for Toxicological Research 1 shared publication Donna L. Mendrick National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Weida Tong NCTR
Advanced Neural Network Applications Carcinogens and Genotoxicity Assessment Computational Drug Discovery Methods
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Wen Zou National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Advanced Neural Network Applications Carcinogens and Genotoxicity Assessment
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Daniel Irabor University of Arkansas at Pine Bluff
Pharmacological Effects and Toxicity Studies Advanced Neural Network Applications Computational Drug Discovery Methods
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Tucker A. Patterson National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Advanced Neural Network Applications Carcinogens and Genotoxicity Assessment
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Joe M. Fowler National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Health and Medical Research Impacts
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Danielle R. Tucker National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Health and Medical Research Impacts
Good match 3 shared topics